Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HIF1AN | Q9NWT6 | 4/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.50 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.47 |
| ▸ | EDNRB | P24530 | 1/20 | 0.46 |
| ▸ | EDNRA | P25101 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL996811 | 1.00 | KDM4E (0.56) | KDM4EALDH1A1HPGDHIF1ANKEAP1 | |
| SCHEMBL995795 | 0.93 | TNFRSF1A (0.52) | KDM4EALDH1A1HPGDHIF1ANTNFRSF1A | |
| SCHEMBL995798 | 0.93 | TNFRSF1A (0.52) | KDM4EALDH1A1HPGDHIF1ANTNFRSF1A | |
| SCHEMBL996370 | 0.92 | ACHE (0.52) | KDM4EALDH1A1HPGDHIF1ANTNFRSF1A | |
| SCHEMBL996372 | 0.92 | ACHE (0.52) | KDM4EALDH1A1HPGDHIF1ANTNFRSF1A | |
| SCHEMBL998259 | 0.88 | KEAP1 (0.59) | KDM4EALDH1A1HIF1ANKEAP1NFE2L2 | |
| SCHEMBL998257 | 0.88 | KEAP1 (0.59) | KDM4EALDH1A1HIF1ANKEAP1NFE2L2 | |
| SCHEMBL997045 | 0.87 | TUBB4A (0.57) | KDM4EALDH1A1HPGDHIF1ANKEAP1 | |
| SCHEMBL997043 | 0.87 | TUBB4A (0.57) | KDM4EALDH1A1HPGDHIF1ANKEAP1 | |
| SCHEMBL997737 | 0.86 | KDM4E (0.51) | KDM4EALDH1A1HPGDHIF1ANKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009826-A2 | NOVEL CHALCONE DERIVATIVES WITH CYTOTOXIC ACTIVITY | ADAMED Sp.z o.o. (PL) | 2011-01-27 | — | — | WO | disclosed |