Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 3/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL14157287 | 0.98 | HRH1 (0.45) | HRH1TAAR1KCNH2KDM1AMAOA | |
| SCHEMBL7408836 | 0.88 | HRH1 (0.43) | HRH1TAAR1KCNH2KDM1AMAOA | |
| Hydrochloric Acid SCHEMBL6431866 | 0.86 | HRH1 (0.42) | HRH1TAAR1KCNH2KDM1AMAOA | |
| SCHEMBL522064 | 0.84 | HRH1 (0.56) | HRH1TAAR1KCNH2HTR2ALOXL2 | |
| SCHEMBL9937806 | 0.83 | KCNH2 (0.39) | KCNH2KDM1AMAOAMAOBMBOAT4 | |
| SCHEMBL103724 | 0.82 | — | — | |
| SCHEMBL30846305 | 0.82 | — | — | |
| SCHEMBL1022831 | 0.80 | KCNH2 (0.40) | KCNH2KDM1AMAOAMAOBMBOAT4 | |
| Hydrochloric Acid SCHEMBL2768799 | 0.80 | KDM1A (0.39) | HRH1KCNH2KDM1AMAOAMAOB | |
| SCHEMBL6434949 | 0.78 | KDM1A (0.41) | KCNH2KDM1AMAOAMAOBMBOAT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118647270-A | Novel derivatives of non-coding amino acids and their use as herbicides | 福提费斯特有限公司 | 2024-09-13 | — | — | CN | claimed |
| WO-2023131951-A1 | NOVEL DERIVATIVES OF NON-CODED AMINO ACIDS AND THEIR USE AS HERBICIDES | FORTEPHEST LTD. (IL) | 2023-07-13 | — | — | WO | claimed |
| CN-118647270-A | Novel derivatives of non-coding amino acids and their use as herbicides | 福提费斯特有限公司 | 2024-09-13 | — | — | CN | disclosed |
| WO-2023131951-A1 | NOVEL DERIVATIVES OF NON-CODED AMINO ACIDS AND THEIR USE AS HERBICIDES | FORTEPHEST LTD. (IL) | 2023-07-13 | — | — | WO | disclosed |
| EP-3877356-A1 | BICYCLIC COMPOUNDS | Vivace Therapeutics, Inc. (US) | 2021-09-15 | — | — | EP | disclosed |
| US-8883826-B2 | Alkynyl derivatives as modulators of metabotropic glutamate receptors | ADDEX PHARMA SA (CH) | 2014-11-11 | — | — | US | disclosed |
| US-8674106-B2 | Alkynyl derivatives as modulators of metabotropic glutamate receptors | ADDEX PHARMA SA (CH) | 2014-03-18 | — | — | US | disclosed |
| US-20130178631-A1 | NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2013-07-11 | — | — | US | disclosed |
| US-20120277237-A1 | NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2012-11-01 | — | — | US | disclosed |
| US-8173807-B2 | Pyridine, pyrimidine and pyrazine derivatives as GPCR agonists | PROSIDION LIMITED (GB) | 2012-05-08 | — | — | US | disclosed |
| EP-2426115-A2 | Alkynyl derivatives as modulators of metabotropic glutamate receptors | Addex Pharma SA (CH) | 2012-03-07 | — | — | EP | disclosed |
| EP-1838698-B1 | PYRIMIDINE DERIVATIVES AS GPCR AGONISTS | PROSIDION LTD (GB) | 2010-09-01 | — | — | EP | disclosed |
| US-20100035897-A1 | Pyridine, pyrimidine and pyrazine derivatives as gpcr agonists | PROSIDION LIMITED (GB) | 2010-02-11 | — | — | US | disclosed |
| US-20090124625-A1 | NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METATROPIC GLUTAMATE RECEPTORS | ADDEX PHARMACEUTICALS SA (CH) | 2009-05-14 | — | — | US | disclosed |
| EP-1838698-A1 | PYRIMIDINE DERIVATIVES AS GPCR AGONISTS | Prosidion Limited (GB) | 2007-10-03 | — | — | EP | disclosed |
| EP-1765795-A2 | ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharmaceuticals SA (CH) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006070208-A1 | PYRIDINE, PYRIMIDINE AND PYRAZINE DERIVATIVES AS GPCR AGONISTS | PROSIDION LTD. (GB) | 2006-07-06 | — | — | WO | disclosed |
| US-7022724-B2 | Cognition enhancing derivatives of isoxazole triazoloindane GABA-A α5 receptor subunit ligands | MERCK SHARP & DOHME LTD. (GB) | 2006-04-04 | — | — | US | disclosed |
| WO-2005123703-A2 | ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMACEUTICALS SA (CH) | 2005-12-29 | — | — | WO | disclosed |
| US-20040058970-A1 | Cognition enhancing derivatives of isoxazole triazoloindane GABA-A alpha 5 receptor subunit ligands | MERCK SHARP & DOHME LTD. (GB) | 2004-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130178631-A1 | NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | GRM5, GRM1, GRM2 | HRH1 409/4885TAAR1 139/4885KCNH2 644/4885 |
| US-20090124625-A1 | NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METATROPIC GLUTAMATE RECEPTORS | GRM5, GRM2, GRM1 | HRH1 424/4885TAAR1 143/4885KCNH2 724/4885 |
| US-20040058970-A1 | Cognition enhancing derivatives of isoxazole triazoloindane GABA-A alpha 5 receptor subunit ligands | GABRA5, GABRA1, GABRB1 | HRH1 435/4885TAAR1 133/4885KCNH2 1442/4885 |
| US-20120277237-A1 | NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | GRM5, GRM1, GRM2 | HRH1 409/4885TAAR1 139/4885KCNH2 644/4885 |
| US-20100035897-A1 | Pyridine, pyrimidine and pyrazine derivatives as gpcr agonists | GPR119, GPR52, GPR65 | HRH1 358/4885TAAR1 54/4885KCNH2 641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.