Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | SLC6A7 | Q99884 | 6/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL720267 | 0.90 | SLC6A7 (0.56) | ALDH1A1TSHRSLC6A7CSNK1DMAPK14 | |
| SCHEMBL29572108 | 0.90 | SLC6A7 (0.56) | ALDH1A1TSHRSLC6A7CSNK1DMAPK14 | |
| SCHEMBL1753062 | 0.85 | SLC6A7 (0.49) | ALDH1A1TSHRSLC6A7CSNK1DMAPK14 | |
| SCHEMBL5005886 | 0.85 | DRD2 (0.49) | ALDH1A1TSHRSLC6A7CSNK1DMAPK14 | |
| Tt-301 SCHEMBL529969 | 0.85 | CSNK1D (0.60) | ALDH1A1TSHRSLC6A7CSNK1DMAPK14 | |
| SCHEMBL1753099 | 0.85 | CSNK1D (0.60) | ALDH1A1TSHRSLC6A7CSNK1DMAPK14 | |
| Tt-301 SCHEMBL9998818 | 0.84 | CSNK1D (0.59) | ALDH1A1TSHRSLC6A7CSNK1DMAPK14 | |
| Tt-301 SCHEMBL300506 | 0.84 | CSNK1D (0.59) | ALDH1A1TSHRSLC6A7CSNK1DMAPK14 | |
| Tt-301 SCHEMBL529453 | 0.84 | CSNK1D (0.59) | ALDH1A1TSHRSLC6A7CSNK1DMAPK14 | |
| SCHEMBL1753142 | 0.82 | RAB9A (0.53) | ALDH1A1TSHRSLC6A7CSNK1DMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663493-B2 | Pyridazine compounds, compositions and methods | NORTHWESTERN UNIVERSITY (US) | 2017-05-30 | — | — | US | disclosed |
| US-9527819-B2 | Pyridazine compounds, compositions and methods | NORTHWESTERN UNIVERSITY | 2016-12-27 | — | — | US | disclosed |
| US-20160326139-A1 | PYRIDAZINE COMPOUNDS, COMPOSITIONS AND METHODS | NORTHWESTERN UNIVERSITY (US) | 2016-11-10 | — | — | US | disclosed |
| US-9408845-B2 | Formulations containing pyridazine compounds | NORTHWESTERN UNIVERSITY (US) | 2016-08-09 | — | — | US | disclosed |
| US-20150175555-A1 | PYRIDAZINE COMPOUNDS, COMPOSITIONS AND METHODS | NORTHWESTERN UNIVERSITY (US) | 2015-06-25 | — | — | US | disclosed |
| US-20130072496-A1 | FORMULATIONS CONTAINING PYRIDAZINE COMPOUNDS | NORTHWESTERN UNIVERSITY (US) | 2013-03-21 | — | — | US | disclosed |
| US-20120245125-A1 | PYRIDAZINE COMPOUNDS, COMPOSITIONS AND METHODS | UNIVERSITE LOUIS PASTEUR DE STRASBOURG (FR) | 2012-09-27 | — | — | US | disclosed |
| US-20120157410-A1 | COMPOSITIONS AND TREATMENTS USING PYRIDAZINE COMPOUNDS AND CHOLINESTERASE INHIBITORS | U.S. GOVERNMENT (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160326139-A1 | PYRIDAZINE COMPOUNDS, COMPOSITIONS AND METHODS | PSEN1, PSEN2, APP | ALDH1A1 2748/4885TSHR 4117/4885SLC6A7 4015/4885 |
| US-20130072496-A1 | FORMULATIONS CONTAINING PYRIDAZINE COMPOUNDS | TST, SRMS, STS | ALDH1A1 3748/4885TSHR 517/4885SLC6A7 995/4885 |
| US-20120157410-A1 | COMPOSITIONS AND TREATMENTS USING PYRIDAZINE COMPOUNDS AND CHOLINESTERASE INHIBITORS | ACHE, BCHE, BACE1 | ALDH1A1 2113/4885TSHR 3482/4885SLC6A7 2952/4885 |
| US-20120245125-A1 | PYRIDAZINE COMPOUNDS, COMPOSITIONS AND METHODS | PSEN1, PSEN2, APP | ALDH1A1 2691/4885TSHR 4050/4885SLC6A7 3963/4885 |
| US-20150175555-A1 | PYRIDAZINE COMPOUNDS, COMPOSITIONS AND METHODS | PSEN1, PSEN2, APP | ALDH1A1 2748/4885TSHR 4117/4885SLC6A7 4015/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.