Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.33 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.32 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.32 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.32 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL28553774 | 0.79 | TSHR (0.39) | TSHRTDP1ALDH1A1HSD17B10ESR1 | |
| SCHEMBL197123 | 0.79 | TSHR (0.39) | TSHRTDP1ALDH1A1HSD17B10ESR1 | |
| SCHEMBL38744 | 0.79 | TSHR (0.39) | TSHRTDP1ALDH1A1HSD17B10ESR1 | |
| SCHEMBL76000 | 0.79 | TSHR (0.39) | TSHRTDP1ALDH1A1HSD17B10ESR1 | |
| SCHEMBL9763697 | 0.79 | TSHR (0.39) | TSHRTDP1ALDH1A1HSD17B10ESR1 | |
| SCHEMBL29120692 | 0.79 | TSHR (0.39) | TSHRTDP1ALDH1A1HSD17B10ESR1 | |
| SCHEMBL9291948 | 0.78 | TSHR (0.33) | TSHRTDP1ALDH1A1HSD17B10ESR1 | |
| Fluoride SCHEMBL5604818 | 0.76 | TSHR (0.37) | TSHRTDP1ALDH1A1HSD17B10ESR1 | |
| SCHEMBL704206 | 0.76 | ESR1 (0.40) | TSHRTDP1ALDH1A1HSD17B10ESR1 | |
| SCHEMBL705847 | 0.76 | ESR1 (0.40) | TSHRTDP1ALDH1A1HSD17B10ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11261202-B2 | Catalytic reduction of halogenated carbosilanes and halogenated carbodisilanes | L'Air Liquide, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude (FR) | 2022-03-01 | — | — | US | disclosed |
| EP-2580255-B1 | POLYARYLACETYLENES CONTAINING SILOXANE, SILANE, AND CARBORANE MOIETIES | US GOV SEC NAVY (US) | 2016-09-07 | — | — | EP | disclosed |
| US-8440850-B2 | Polyarylacetylenes containing siloxane, silane, and carborane moieties | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2013-05-14 | — | — | US | disclosed |
| EP-2580255-A2 | POLYARYLACETYLENES CONTAINING SILOXANE, SILANE, AND CARBORANE MOIETIES | The Government of the United States of America as represented by the Secretary of the Navy (US) | 2013-04-17 | — | — | EP | disclosed |
| US-8269030-B2 | Polyarylacetylenes containing siloxane, silane, and carborane moieties | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2012-09-18 | — | — | US | disclosed |
| US-20120190808-A1 | POLYARYLACETYLENES CONTAINING SILOXANE, SILANE, AND CARBORANE MOIETIES | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2012-07-26 | — | — | US | disclosed |
| US-20120184699-A1 | POLYARYLACETYLENES CONTAINING SILOXANE, SILANE, AND CARBORANE MOIETIES | The Government of the United State of America, as represented by the Secretary of the Navy (US) | 2012-07-19 | — | — | US | disclosed |
| US-8217194-B2 | Polyarylacetylenes containing siloxane, silane, and carborane moieties | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2012-07-10 | — | — | US | disclosed |
| WO-2011156678-A2 | POLYARYLACETYLENES CONTAINING SILOXANE, SILANE, AND CARBORANE MOIETIES | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2011-12-15 | — | — | WO | disclosed |
| US-20110306744-A1 | POLYARYLACETYLENES CONTAINING SILOXANE, SILANE, AND CARBORANE MOIETIES | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306744-A1 | POLYARYLACETYLENES CONTAINING SILOXANE, SILANE, AND CARBORANE MOIETIES | SIRT2, SUMO2, MCM2 | TSHR 4621/4885TDP1 4376/4885ALDH1A1 3215/4885 |
| US-20120190808-A1 | POLYARYLACETYLENES CONTAINING SILOXANE, SILANE, AND CARBORANE MOIETIES | SIRT2, SUMO2, MCM2 | TSHR 4394/4885TDP1 4292/4885ALDH1A1 3588/4885 |
| US-20120184699-A1 | POLYARYLACETYLENES CONTAINING SILOXANE, SILANE, AND CARBORANE MOIETIES | SIRT2, SUMO2, MCM2 | TSHR 4632/4885TDP1 4375/4885ALDH1A1 3126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.