Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2102622 | 0.80 | KCNH2 (0.39) | TP53TSHRALDH1A1GLACHRM2 | |
| SCHEMBL2271289 | 0.80 | TP53 (0.36) | TP53TSHRALDH1A1GLACHRM2 | |
| SCHEMBL2100019 | 0.80 | TP53 (0.36) | TP53TSHRALDH1A1GLACHRM2 | |
| SCHEMBL2272577 | 0.78 | ESR1 (0.37) | TP53TSHRALDH1A1GLACHRM2 | |
| SCHEMBL2102653 | 0.78 | ESR1 (0.37) | TP53TSHRALDH1A1GLACHRM2 | |
| SCHEMBL10626373 | 0.78 | ESR1 (0.37) | TP53TSHRALDH1A1GLACHRM2 | |
| SCHEMBL9052501 | 0.76 | ESR1 (0.35) | TP53TSHRALDH1A1GLACHRM2 | |
| SCHEMBL2101348 | 0.76 | TP53 (0.33) | TP53TSHRALDH1A1GLACHRM2 | |
| SCHEMBL2101359 | 0.76 | TSHR (0.33) | TP53TSHRALDH1A1GLACHRM2 | |
| SCHEMBL2101242 | 0.76 | ALDH1A1 (0.33) | TP53TSHRALDH1A1GLACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2580255-B1 | POLYARYLACETYLENES CONTAINING SILOXANE, SILANE, AND CARBORANE MOIETIES | US GOV SEC NAVY (US) | 2016-09-07 | — | — | EP | disclosed |
| US-8440850-B2 | Polyarylacetylenes containing siloxane, silane, and carborane moieties | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2013-05-14 | — | — | US | disclosed |
| EP-2580255-A2 | POLYARYLACETYLENES CONTAINING SILOXANE, SILANE, AND CARBORANE MOIETIES | The Government of the United States of America as represented by the Secretary of the Navy (US) | 2013-04-17 | — | — | EP | disclosed |
| US-8269030-B2 | Polyarylacetylenes containing siloxane, silane, and carborane moieties | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2012-09-18 | — | — | US | disclosed |
| US-20120190808-A1 | POLYARYLACETYLENES CONTAINING SILOXANE, SILANE, AND CARBORANE MOIETIES | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2012-07-26 | — | — | US | disclosed |
| US-20120184699-A1 | POLYARYLACETYLENES CONTAINING SILOXANE, SILANE, AND CARBORANE MOIETIES | The Government of the United State of America, as represented by the Secretary of the Navy (US) | 2012-07-19 | — | — | US | disclosed |
| US-8217194-B2 | Polyarylacetylenes containing siloxane, silane, and carborane moieties | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2012-07-10 | — | — | US | disclosed |
| WO-2011156678-A2 | POLYARYLACETYLENES CONTAINING SILOXANE, SILANE, AND CARBORANE MOIETIES | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2011-12-15 | — | — | WO | disclosed |
| US-20110306744-A1 | POLYARYLACETYLENES CONTAINING SILOXANE, SILANE, AND CARBORANE MOIETIES | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306744-A1 | POLYARYLACETYLENES CONTAINING SILOXANE, SILANE, AND CARBORANE MOIETIES | SIRT2, SUMO2, MCM2 | TP53 1398/4885TSHR 4621/4885ALDH1A1 3215/4885 |
| US-20120190808-A1 | POLYARYLACETYLENES CONTAINING SILOXANE, SILANE, AND CARBORANE MOIETIES | SIRT2, SUMO2, MCM2 | TP53 1506/4885TSHR 4394/4885ALDH1A1 3588/4885 |
| US-20120184699-A1 | POLYARYLACETYLENES CONTAINING SILOXANE, SILANE, AND CARBORANE MOIETIES | SIRT2, SUMO2, MCM2 | TP53 1305/4885TSHR 4632/4885ALDH1A1 3126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.