Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | USP2 | O75604 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | WDR5 | P61964 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12065843 | 0.82 | TNNI3K (0.48) | KMT2AWDR5 | |
| SCHEMBL9980411 | 0.81 | CYP1A2 (0.45) | KMT2AUSP2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9980382 | 0.78 | USP2 (0.36) | KMT2AUSP2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9980424 | 0.76 | TNNI3K (0.35) | FFAR2CYP2D6LMNACA1CA2 | |
| SCHEMBL9980493 | 0.75 | TNNI3K (0.36) | FFAR2ALDH1A1CYP2D6CA1CA2 | |
| SCHEMBL9980448 | 0.74 | LRRK2 (0.42) | ALDH1A1CA1CA2LRRK2 | |
| SCHEMBL9980404 | 0.73 | STK4 (0.39) | KMT2AALDH1A1TSHRMEN1HSD17B10 | |
| SCHEMBL9980436 | 0.71 | TNNI3K (0.37) | KMT2AWDR5CA1CA2CA7 | |
| SCHEMBL9986489 | 0.71 | TNNI3K (0.52) | KMT2AWDR5 | |
| SCHEMBL12066469 | 0.70 | TNNI3K (0.53) | KMT2AWDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | claimed |
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | disclosed |