Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | WRN | Q14191 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18048859 | 0.83 | MGAM (0.39) | — | |
| SCHEMBL4786240 | 0.82 | TRPA1 (0.34) | ALDH1A1CYP2C19 | |
| SCHEMBL6025638 | 0.82 | — | — | |
| SCHEMBL27814945 | 0.81 | NAAA (0.39) | NAAAALDH1A1CYP1A2HPGDCYP2C19 | |
| SCHEMBL23355066 | 0.79 | KDM2A (0.33) | — | |
| SCHEMBL4326668 | 0.78 | ALDH1A1 (0.36) | ALDH1A1 | |
| SCHEMBL133605 | 0.77 | — | — | |
| SCHEMBL4969192 | 0.77 | LMNA (0.37) | ALDH1A1 | |
| SCHEMBL6767253 | 0.77 | TSHR (0.40) | — | |
| SCHEMBL1742070 | 0.76 | RECQL (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773659-A2 | FIBRONECTIN BINDING DOMAINS WITH REDUCED IMMUNOGENICITY | Bristol-Myers Squibb Company (US) | 2014-09-10 | — | — | EP | disclosed |
| WO-2013067029-A9 | FIBRONECTIN BINDING DOMAINS WITH REDUCED IMMUNOGENICITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-09-06 | — | — | WO | disclosed |
| WO-2013067029-A2 | FIBRONECTIN BINDING DOMAINS WITH REDUCED IMMUNOGENICITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-05-10 | — | — | WO | disclosed |
| EP-2576615-A2 | FIBRONECTIN BASED SCAFFOLD PROTEINS HAVING IMPROVED STABILITY | Bristol-Myers Squibb Pharma Company (US) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011150133-A2 | FIBRONECTIN BASED SCAFFOLD PROTEINS HAVING IMPROVED STABILITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-12-01 | — | — | WO | disclosed |