Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4070047 | 0.78 | TYMS (0.38) | TYMSALDH1A1TDP1BLMCYP3A4 | |
| SCHEMBL727348 | 0.74 | TYMS (0.44) | TYMSALDH1A1TDP1GRIN2DGRIN3B | |
| SCHEMBL21067279 | 0.74 | SMN1; SMN2 (0.37) | TYMSALDH1A1TDP1BLMCYP3A4 | |
| SCHEMBL3919290 | 0.69 | TYMS (0.47) | TYMSALDH1A1TDP1GRIN2DGRIN3B | |
| SCHEMBL1716189 | 0.67 | TYMS (0.44) | TYMSALDH1A1TDP1BLMMAPT | |
| SCHEMBL15717554 | 0.65 | ALDH1A1 (0.48) | TYMSALDH1A1TDP1GRIN2DGRIN3B | |
| SCHEMBL9871854 | 0.65 | ALDH1A1 (0.39) | ALDH1A1TDP1MAPTNPC1LMNA | |
| SCHEMBL9119626 | 0.65 | TSHR (0.44) | ALDH1A1TDP1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL14608804 | 0.64 | MEN1 (0.47) | ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL30992734 | 0.64 | MEN1 (0.39) | ALDH1A1TDP1GALR3GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11091509-B2 | HPPK inhibitors useful as antibacterial agents | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2021-08-17 | — | — | US | disclosed |
| US-20190241605-A1 | HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2019-08-08 | — | — | US | disclosed |
| WO-2018071531-A1 | HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2018-04-19 | — | — | WO | disclosed |
| US-20160368944-A1 | LINKED PURINE PTERIN HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS | US HEALTH (US) | 2016-12-22 | — | — | US | disclosed |
| US-9453019-B2 | Linked purine pterin HPPK inhibitors useful as antibacterial agents | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2016-09-27 | — | — | US | disclosed |
| US-20150218167-A1 | LINKED PURINE PTERIN HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS | US HEALTH (US) | 2015-08-06 | — | — | US | disclosed |
| US-9029344-B2 | Linked purine pterin HPPK inhibitors useful as antibacterial agents | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2015-05-12 | — | — | US | disclosed |
| US-20130172285-A1 | LINKED PURINE PTERIN HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2013-07-04 | — | — | US | disclosed |
| EP-2582712-A2 | LINKED PURINE PTERIN HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services (US) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011159471-A2 | LINKED PURINE PTERIN HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368944-A1 | LINKED PURINE PTERIN HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS | PDXK, HPRT1, PLPBP | TYMS 67/4885ALDH1A1 3443/4885TDP1 818/4885 |
| US-20130172285-A1 | LINKED PURINE PTERIN HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS | PDXK, HPRT1, PLPBP | TYMS 57/4885ALDH1A1 3507/4885TDP1 775/4885 |
| US-20190241605-A1 | HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS | PDXK, PHKG1, DTYMK | TYMS 74/4885ALDH1A1 3219/4885TDP1 649/4885 |
| US-20150218167-A1 | LINKED PURINE PTERIN HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS | PDXK, HPRT1, PLPBP | TYMS 57/4885ALDH1A1 3507/4885TDP1 775/4885 |
| US-11091509-B2 | HPPK inhibitors useful as antibacterial agents | PDXK, PHKG1, DTYMK | TYMS 74/4885ALDH1A1 3219/4885TDP1 649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.