Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4816673 | 0.83 | TSHR (0.43) | KMT2AHPGDMAPTL3MBTL1MEN1 | |
| SCHEMBL11285004 | 0.81 | L3MBTL1 (0.44) | KMT2APTGS1HPGDMAPTL3MBTL1 | |
| SCHEMBL11276127 | 0.81 | GAA (0.41) | HPGDMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL27447903 | 0.81 | KMT2A (0.42) | KMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL4016238 | 0.79 | PTGS2 (0.46) | KMT2APTGS1PTGS2HPGDMAPT | |
| SCHEMBL11286164 | 0.79 | ALDH1A1 (0.49) | KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL3539841 | 0.78 | KMT2A (0.40) | KMT2AMAPTL3MBTL1MEN1ALDH1A1 | |
| SCHEMBL11043246 | 0.78 | EPHX1 (0.37) | KMT2APTGS2MAPTL3MBTL1KDM1A | |
| SCHEMBL11409716 | 0.77 | NLRP3 (0.45) | KMT2AMEN1ALDH1A1KDM4ETSHR | |
| SCHEMBL11281869 | 0.77 | LMNA (0.40) | KMT2AHPGDMAPTL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2456435-A1 | HETEROARYL BENZAMIDES, COMPOSITIONS AND METHODS OF USE | The Board of Trustees of The Leland Stanford Junior University (US) | 2012-05-30 | — | — | EP | disclosed |
| WO-2011011514-A1 | HETEROARYL BENZAMIDES, COMPOSITIONS AND METHODS OF USE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2011-01-27 | — | — | WO | disclosed |