Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2698690 | 1.00 | PLG (0.41) | PLGPLATLMNAANPEPENPEP | |
| SCHEMBL29602455 | 0.83 | MGLL (0.37) | BRD4MGLLALDH1A1POLB | |
| SCHEMBL18625762 | 0.83 | BRD4 (0.32) | BRD4MGLL | |
| SCHEMBL14664454 | 0.82 | HPGD (0.37) | KMT2ABRD4ALDH1A1POLB | |
| SCHEMBL18610478 | 0.82 | HPGD (0.37) | KMT2ABRD4ALDH1A1POLB | |
| SCHEMBL3643958 | 0.82 | PLG (0.38) | PLGPLATLMNAANPEPENPEP | |
| SCHEMBL22009028 | 0.78 | BRD4 (0.39) | BRD4MGLLALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL23760484 | 0.77 | ALDH1A1 (0.33) | LMNABRD4ALDH1A1 | |
| SCHEMBL10105716 | 0.77 | ALDH1A1 (0.33) | LMNABRD4ALDH1A1 | |
| SCHEMBL13532310 | 0.75 | MGLL (0.34) | BRD4MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451792-A2 | PROCESS FOR SUBSTITUTED 3-AMINO-5-OXO-4,5-DIHYDRO-[1,2,4]TRIAZINES | OSI Pharmaceuticals, LLC (US) | 2012-05-16 | — | — | EP | claimed |
| US-20120108812-A1 | PROCESS FOR SUBSTITUTED 3-AMINO-5-OXO-4,5-DIHYDRO-[1,2,4]TRIAZINES | OSI PHARMACEUTICALS ,INC. | 2012-05-03 | — | — | US | claimed |
| WO-2011005909-A2 | PROCESS FOR SUBSTITUTED 3-AMINO-5-OXO-4,5-DIHYDRO-[1,2,4]TRIAZINES | OSI PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | claimed |
| EP-2451792-A2 | PROCESS FOR SUBSTITUTED 3-AMINO-5-OXO-4,5-DIHYDRO-[1,2,4]TRIAZINES | OSI Pharmaceuticals, LLC (US) | 2012-05-16 | — | — | EP | disclosed |
| US-20120108812-A1 | PROCESS FOR SUBSTITUTED 3-AMINO-5-OXO-4,5-DIHYDRO-[1,2,4]TRIAZINES | OSI PHARMACEUTICALS ,INC. | 2012-05-03 | — | — | US | disclosed |
| WO-2011005909-A2 | PROCESS FOR SUBSTITUTED 3-AMINO-5-OXO-4,5-DIHYDRO-[1,2,4]TRIAZINES | OSI PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108812-A1 | PROCESS FOR SUBSTITUTED 3-AMINO-5-OXO-4,5-DIHYDRO-[1,2,4]TRIAZINES | ALKBH5, NT5C, CYP4Z1 | PLG 3176/4885PLAT 2798/4885LMNA 2623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.