Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9988636 | 0.84 | ALDH1A1 (0.37) | L3MBTL1ALDH1A1TDP1HSP90AA1DCUN1D1 | |
| SCHEMBL9987892 | 0.78 | HSD11B1 (0.42) | ALDH1A1TDP1GAAHSD11B1HSP90AA1 | |
| SCHEMBL9988458 | 0.74 | PDE2A (0.42) | L3MBTL1ALDH1A1TDP1HSD11B1CASP3 | |
| SCHEMBL17034486 | 0.71 | L3MBTL1 (0.48) | L3MBTL1ALDH1A1TDP1GAAHSD11B1 | |
| SCHEMBL27293196 | 0.69 | CYP1A2 (0.51) | L3MBTL1ALDH1A1TDP1GAAHSP90AA1 | |
| SCHEMBL9987959 | 0.69 | LMNA (0.43) | L3MBTL1ALDH1A1GAACASP3SENP8 | |
| SCHEMBL1969571 | 0.67 | DPP4 (0.41) | ALDH1A1TDP1HSD11B1DPP4HPGD | |
| SCHEMBL18015824 | 0.67 | ALDH1A1 (0.73) | L3MBTL1ALDH1A1TDP1GAAHPGD | |
| SCHEMBL15636515 | 0.66 | DPP4 (0.40) | L3MBTL1ALDH1A1TDP1HSD11B1DPP4 | |
| SCHEMBL16770866 | 0.66 | CASP3 (0.60) | ALDH1A1CASP3SENP8SENP7SENP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2397462-A2 | Compounds, compositions and methods of treatment for heart failure | Cytokinetics, Inc. (US) | 2011-12-21 | — | — | EP | claimed |