Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 6/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.42 |
| ▸ | PDE6D | O43924 | 1/20 | 0.41 |
| ▸ | PDE6A | P16499 | 1/20 | 0.41 |
| ▸ | PDE6G | P18545 | 1/20 | 0.41 |
| ▸ | PDE6B | P35913 | 1/20 | 0.41 |
| ▸ | PDE6C | P51160 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987892 | 0.78 | HSD11B1 (0.42) | ALDH1A1NPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL9987959 | 0.75 | LMNA (0.43) | L3MBTL1ALDH1A1NPC1TP53RAB9A | |
| SCHEMBL9987986 | 0.74 | L3MBTL1 (0.37) | L3MBTL1ALDH1A1NPC1TP53RAB9A | |
| SCHEMBL491297 | 0.71 | — | — | |
| SCHEMBL9988636 | 0.71 | ALDH1A1 (0.37) | L3MBTL1ALDH1A1NPC1TP53RAB9A | |
| SCHEMBL1969571 | 0.67 | DPP4 (0.41) | ALDH1A1NPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL9453855 | 0.66 | CYP2A6 (0.38) | L3MBTL1ALDH1A1NPC1TP53RAB9A | |
| SCHEMBL9453856 | 0.66 | ERN1 (0.43) | L3MBTL1ALDH1A1NPC1TP53RAB9A | |
| SCHEMBL5670544 | 0.66 | MEN1 (0.40) | PDE2APDE10AL3MBTL1NFE2L2ALDH1A1 | |
| SCHEMBL9988624 | 0.66 | IDO1 (0.41) | ALDH1A1HSD11B1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2397462-A2 | Compounds, compositions and methods of treatment for heart failure | Cytokinetics, Inc. (US) | 2011-12-21 | — | — | EP | claimed |