Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | RXRB | P28702 | 1/20 | 0.47 |
| ▸ | RXRG | P48443 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ILK | Q13418 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9989408 | 0.92 | DRD4 (0.51) | RXRARXRBRXRGALOX5SMN1; SMN2 | |
| SCHEMBL9988671 | 0.91 | ALOX5 (0.48) | LMNARXRARXRBRXRGALOX5 | |
| SCHEMBL9988576 | 0.87 | LMNA (0.47) | LMNATP53RXRARXRBRXRG | |
| SCHEMBL9988823 | 0.85 | RXRA (0.43) | LMNATP53RXRARXRBRXRG | |
| SCHEMBL9988515 | 0.84 | MC4R (0.53) | LMNATP53RXRARXRBRXRG | |
| SCHEMBL9988387 | 0.84 | DRD4 (0.49) | PTGS2SMN1; SMN2POLBKDM4EKDM5B | |
| SCHEMBL9990141 | 0.83 | RXRA (0.51) | LMNATP53RXRARXRBRXRG | |
| SCHEMBL9989583 | 0.83 | CCKAR (0.42) | LMNATP53RXRARXRBRXRG | |
| SCHEMBL9988521 | 0.83 | TP53 (0.42) | LMNATP53RXRARXRBRXRG | |
| SCHEMBL9990088 | 0.83 | RXRA (0.45) | LMNATP53RXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011161615-A1 | 5-LIPOXYGENASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2011-12-29 | — | — | WO | claimed |
| WO-2011161615-A1 | 5-LIPOXYGENASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2011-12-29 | — | — | WO | disclosed |