Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 4/20 | 0.55 |
| ▸ | CA2 | P00918 | 4/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | ACR | P10323 | 3/20 | 0.51 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953733 | 0.88 | RAB9A (0.53) | RAB9AMAPTCASP3SENP8SENP7 | |
| SCHEMBL9748412 | 0.85 | HSD17B10 (0.46) | RAB9AMAPTCASP3SENP8SENP7 | |
| SCHEMBL11646899 | 0.85 | RAB9A (0.59) | RAB9AMAPTCASP3SENP8SENP7 | |
| SCHEMBL445414 | 0.83 | RAB9A (0.58) | RAB9AMAPTCASP3SENP8SENP7 | |
| SCHEMBL1457515 | 0.81 | MAPT (0.56) | RAB9AMAPTCA1CA2TDP1 | |
| SCHEMBL2590530 | 0.81 | CA1 (0.45) | RAB9AMAPTCASP3SENP8SENP7 | |
| SCHEMBL29754225 | 0.80 | ALDH1A1 (0.48) | RAB9AMAPTCASP3SENP8SENP7 | |
| SCHEMBL1421363 | 0.80 | ALDH1A1 (0.48) | RAB9AMAPTCASP3SENP8SENP7 | |
| SCHEMBL9748423 | 0.79 | MIF (0.53) | RAB9AMAPTCASP3SENP8SENP7 | |
| SCHEMBL1308638 | 0.79 | NOS3 (0.53) | RAB9AMAPTL3MBTL1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104219954-B | Benzamide derivatives | 翻译基因组学研究院 | 2017-03-22 | — | — | CN | claimed |
| EP-2445345-B1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL GENOMICS RES INST (US) | 2014-08-27 | — | — | EP | claimed |
| US-10590088-B2 | 4-(benzimidazol-2-ylamino)benzamide derivatives and methods of synthesis thereof | TRANSLATIONAL DRUG DEVELOPMENT, LLC (US) | 2020-03-17 | — | — | US | disclosed |
| US-10590088-B2 | 4-(benzimidazol-2-ylamino)benzamide derivatives and methods of synthesis thereof | TRANSLATIONAL DRUG DEVELOPMENT, LLC (US) | 2020-03-17 | — | — | US | disclosed |
| US-20190084940-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2019-03-21 | — | — | US | disclosed |
| US-20190084940-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2019-03-21 | — | — | US | disclosed |
| CN-104219954-B | Benzamide derivatives | 翻译基因组学研究院 | 2017-03-22 | — | — | CN | disclosed |
| US-20160362382-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2016-12-15 | — | — | US | disclosed |
| US-9464059-B2 | Benzamide derivatives | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2016-10-11 | — | — | US | disclosed |
| US-20150284336-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2015-10-08 | — | — | US | disclosed |
| US-9125901-B2 | 4-(benzimidazol-2-ylamino)benzamide derivatives and salts or solvates thereof | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2015-09-08 | — | — | US | disclosed |
| WO-2000025768-A1 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2000-05-11 | — | — | WO | disclosed |
| WO-1999021845-A2 | 4-AMINOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 1999-05-06 | — | — | WO | disclosed |
| EP-0355819-B1 | Substituted aryl ureas as high potency sweeteners | NUTRASWEET CO (US) | 1994-01-05 | — | — | EP | disclosed |
| EP-0299533-B1 | HIGH POTENCY SWEETENING AGENTS | THE NUTRASWEET COMPANY (a Delaware corporation) (US) | 1993-04-07 | — | — | EP | disclosed |
| CN-1043125-A | Be used as the aryl urea of the replacement of high-potency sweetener | NUTRASWEET CO (US) | 1990-06-20 | — | — | CN | disclosed |
| EP-0355819-A1 | Substituted aryl ureas as high potency sweeteners | THE NUTRASWEET COMPANY (a Delaware corporation) (US) | 1990-02-28 | — | — | EP | disclosed |
| CN-1033624-A | High-potency sweetener | NUTRASWEET CO (US) | 1989-07-05 | — | — | CN | disclosed |
| WO-1989000563-A1 | HIGH POTENCY SWEETENING AGENTS | THE NUTRASWEET COMPANY (US) | 1989-01-26 | — | — | WO | disclosed |
| EP-0299533-A2 | High potency sweetening agents | THE NUTRASWEET COMPANY (a Delaware corporation) (US) | 1989-01-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10590088-B2 | 4-(benzimidazol-2-ylamino)benzamide derivatives and methods of synthesis thereof | MCL1, BRDT, BOD1L1 | RAB9A 858/4885MAPT 4683/4885CASP3 342/4885 |
| US-20150284336-A1 | BENZAMIDE DERIVATIVES | BRDT, BRD3, BRD2 | RAB9A 1578/4885MAPT 4124/4885CASP3 184/4885 |
| US-20160362382-A1 | BENZAMIDE DERIVATIVES | BRDT, BRD3, BRD2 | RAB9A 1578/4885MAPT 4124/4885CASP3 184/4885 |
| US-20190084940-A1 | BENZAMIDE DERIVATIVES | BRDT, BRD3, BRD2 | RAB9A 1578/4885MAPT 4124/4885CASP3 184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.