Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 4/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.61 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.61 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.61 |
| ▸ | APEX1 | P27695 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | RECQL | P46063 | 3/20 | 0.46 |
| ▸ | BLM | P54132 | 3/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2760850 | 0.78 | ADRA2A (0.66) | ADRA2AADRA2BADRA2CADRA1AADRB2 | |
| SCHEMBL7149381 | 0.76 | KIF11 (0.46) | ADRA2AADRA2BADRA2CADRA1AADRB2 | |
| SCHEMBL7145434 | 0.76 | ADRA2A (0.61) | ADRA2AADRA2BADRA2CADRA1AADRB2 | |
| SCHEMBL29374680 | 0.76 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1AADRB2 | |
| SCHEMBL11850533 | 0.75 | ADRB1 (0.68) | ADRA2AADRA2BADRA2CADRA1AADRB2 | |
| SCHEMBL7150216 | 0.75 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CADRA1AADRB2 | |
| SCHEMBL11841871 | 0.74 | ADRB2 (0.56) | ADRA2AADRA2BADRA2CADRA1AADRB2 | |
| SCHEMBL10388923 | 0.73 | ADRA2A (0.40) | ADRA2AADRA2BADRA2CADRA1AADRB2 | |
| SCHEMBL30557720 | 0.73 | ADRA2A (0.37) | ADRA2AADRA2BADRA2CADRA1AADRB2 | |
| SCHEMBL12380944 | 0.72 | GABRA1 (0.46) | ADRA2AADRA2BADRA2CADRA1AADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997030036-A1 | ARYL DERIVATIVES | NOVARTIS AG (CH) | 1997-08-21 | — | — | WO | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |
| US-4297096-A | HYPOTENSIVE AGENTS; MUSCLE RELAXANTS; STREPTOMYCES CULTURE | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 1981-10-27 | — | — | US | disclosed |