SCHEMBL146921

SCHEMBL146921

O=C(Nc1ncn[nH]1)c1cccnc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALPL P05186 6/20 0.60
▸ F2 P00734 1/20 0.60
▸ LMNA P02545 1/20 0.56
▸ HIF1A Q16665 1/20 0.56
▸ NPC1 O15118 2/20 0.56
▸ RAB9A P51151 2/20 0.56
▸ SMN1; SMN2 Q16637 2/20 0.56
▸ PIM1 P11309 1/20 0.56
▸ PIM3 Q86V86 1/20 0.56
▸ PIM2 Q9P1W9 1/20 0.56
▸ ROCK2 O75116 1/20 0.55
▸ ROCK1 Q13464 1/20 0.55
▸ L3MBTL1 Q9Y468 1/20 0.54
▸ KDM4E B2RXH2 1/20 0.54
▸ POLB P06746 1/20 0.54
▸ SIRT2 Q8IXJ6 1/20 0.53
▸ HDAC1 Q13547 2/20 0.53
▸ HDAC6 Q9UBN7 1/20 0.53
▸ CLK2 P49760 1/20 0.52
▸ CLK3 P49761 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL148344 0.83 ALPL (0.68) ALPLF2LMNANPC1RAB9A
SCHEMBL11780084 0.78 LMNA (0.58) LMNAHIF1ANPC1RAB9ASMN1; SMN2
SCHEMBL153149 0.78 LMNA (0.58) LMNAHIF1ANPC1RAB9ASMN1; SMN2
SCHEMBL11591993 0.75 LMNA (0.63) LMNAHIF1ANPC1RAB9ASMN1; SMN2
SCHEMBL6643666 0.74 LMNA (0.67) LMNAHIF1ANPC1RAB9ASMN1; SMN2
SCHEMBL19520187 0.73 LMNA (0.81) LMNAHIF1ANPC1RAB9ASMN1; SMN2
SCHEMBL1571386 0.73 LMNA (1.00) LMNAHIF1ANPC1RAB9APIM1
SCHEMBL11591966 0.73 LMNA (0.69) LMNAHIF1ANPC1RAB9ASMN1; SMN2
SCHEMBL9371060 0.72 EPHX1 (0.56) ALPLF2NPC1RAB9ASMN1; SMN2
SCHEMBL10870632 0.72 HDAC1 (0.49) LMNAHIF1ANPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2773625-B1 5-PHENYL SUBSTITUTED N-(TETRAZOL-5-YL)- AND N-(TRIAZOL-5-YL)ARYL CARBOXYLIC ACID AMIDES AND USE OF SAME AS HERBICIDES BAYER IP GMBH (DE) 2016-08-24 — — EP disclosed
CN-103282354-B N-(tetrazolium-5-yl)-and N-(triazole-5-yl) aryl carboxamides and as the purposes of herbicide BAYER INTELLECTUAL PROPERTY GMBH (DE) 2016-05-04 — — CN disclosed
US-9259001-B2 5-phenyl-substituted N-(tetrazol-5-yl) aryl carboxylic acid amides and N-(triazol-5-yl) aryl carboxylic acid amides, and use thereof as herbicides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2016-02-16 — — US disclosed
US-9169219-B2 Herbicidally active 4-nitro-substituted N-(tetrazol-5-yl)-, N-(triazol-5-yl)-, and N-(1,3,4-0XADIAZOL-2-yl)aryl carboxylic acid amides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-10-27 — — US disclosed
EP-2773626-B1 HERBICIDALLY ACTIVE OXIME-ETHER-SUBSTITUTED BENZOYLAMIDES BAYER IP GMBH (DE) 2015-08-05 — — EP disclosed
US-9035067-B2 N-(1,2,5-Oxadiazol-3-yl)-, N-(tetrazol-5-yl)- and N-(triazol-5-yl)bicycloarylcarboxamides and their use as herbicides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-05-19 — — US disclosed
EP-2739611-B1 N-(TETRAZOL-5-YL)- AND N-(TRIAZOL-5-YL)ARYL CARBOXAMIDES AND THEIR USE AS HEBICIDES BAYER IP GMBH (DE) 2015-05-13 — — EP disclosed
US-8957096-B2 Herbicidally active oxime-ether-substituted benzoylamides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-02-17 — — US disclosed
US-20150031537-A1 HERBICIDALLY ACTIVE 4-NITRO-SUBSTITUTED N-(TETRAZOL-5-YL)-, N-(TRIAZOL-5-YL)-, AND N-(1,3,4-OXADIAZOL-2-YL)ARYL CARBOXYLIC ACID AMIDES BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-01-29 — — US disclosed
EP-2686315-B1 N-(1,2,5-OXADIAZOL-3-YL)-, N-(TETRAZOL-5-YL)- AND N-(TRIAZOL-5-YL)BICYCLOARYLCARBOXAMIDES AND THEIR USE AS HERBICIDES BAYER IP GMBH (DE) 2015-01-14 — — EP disclosed
CN-103282354-A N-(tetrazol-5-l)- and n-(triazol-5-yl)arylcarboxamides and use thereof as herbicides BAYER IP GMBH 2013-09-04 — — CN disclosed
EP-2611785-A1 N-(TETRAZOL-5-YL)- AND N-(TRIAZOL-5-YL)ARYLCARBOXAMIDES AND USE THEREOF AS HERBICIDES Bayer Intellectual Property GmbH (DE) 2013-07-10 — — EP disclosed
US-8481749-B2 N-(tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxamides and their use as herbicides BAYER CROPSCIENCE AG (DE) 2013-07-09 — — US disclosed
WO-2013064459-A1 HERBICIDALLY ACTIVE OXIME-ETHER-SUBSTITUTED BENZOYLAMIDES BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-05-10 — — WO disclosed
WO-2013064457-A1 5-PHENYL-SUBSTITUTED N-(TETRAZOL-5-YL) ARYL CARBOXYLIC ACID AMIDES AND N-(TRIAZOL-5-YL) ARYL CARBOXYLIC ACID AMIDES, AND USE THEREOF AS HERBICIDES BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-05-10 — — WO disclosed
EP-2589598-A1 5-phenyl substituted N-(Tetrazol-5-yl)- and N-(Triazol-5-yl)aryl carboxylic acid amides and use of same as herbicides Bayer CropScience AG (DE) 2013-05-08 — — EP disclosed
WO-2013017559-A1 N-(TETRAZOL-5-YL)- AND N-(TRIAZOL-5-YL)ARYLCARBOXAMIDES AND USE THEREOF AS HERBICIDES BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-02-07 — — WO disclosed
WO-2012123409-A1 N-(1,2,5-OXADIAZOL-3-YL)-, N-(TETRAZOL-5-YL)- AND N-(TRIAZOL-5-YL)BICYCLOARYLCARBOXAMIDES AND THEIR USE AS HERBICIDES BAYER CROPSCIENCE AG (DE) 2012-09-20 — — WO disclosed
US-20120058892-A1 N-(TETRAZOL-5-YL)- AND N-(TRIAZOL-5-YL)ARYLCARBOXAMIDES AND THEIR USE AS HERBICIDES BAYER CROPSCIENCE AG (US) 2012-03-08 — — US disclosed
WO-2012028579-A1 N-(TETRAZOL-5-YL)- AND N-(TRIAZOL-5-YL)ARYLCARBOXAMIDES AND USE THEREOF AS HERBICIDES BAYER CROPSCIENCE AG (DE) 2012-03-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120058892-A1 N-(TETRAZOL-5-YL)- AND N-(TRIAZOL-5-YL)ARYLCARBOXAMIDES AND THEIR USE AS HERBICIDES ZYX, NAT1, CYCS ALPL 1665/4885F2 3439/4885LMNA 1711/4885
US-20150031537-A1 HERBICIDALLY ACTIVE 4-NITRO-SUBSTITUTED N-(TETRAZOL-5-YL)-, N-(TRIAZOL-5-YL)-, AND N-(1,3,4-OXADIAZOL-2-YL)ARYL CARBOXYLIC ACID AMIDES AADAC, NAT1, AOX1 ALPL 1232/4885F2 3745/4885LMNA 3227/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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