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Sugi Predict / Targets / ARHGEF12

ARHGEF12

Rho guanine nucleotide exchange factor 12 · Q9NZN5 · ARHGEF12 on Sugi Atlas →

200 patent compounds predicted against ARHGEF12, 177 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL15936914 SCHEMBL15936914 1.00 1/20
SCHEMBL15936925 SCHEMBL15936925 1.00 1/20
SCHEMBL17603571 SCHEMBL17603571 1.00 1/20
SCHEMBL19665210 SCHEMBL19665210 1.00 1/20
SCHEMBL20175987 SCHEMBL20175987 1.00 1/20
SCHEMBL25138474 SCHEMBL25138474 1.00 1/20
SCHEMBL29372342 SCHEMBL29372342 1.00 1/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL29557889) 0.98 1/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL29557944) 0.98 1/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL31717447) 0.98 1/20
SCHEMBL24863333 SCHEMBL24863333 0.81 1/20
SCHEMBL20180895 SCHEMBL20180895 0.78 1/20
SCHEMBL19685492 SCHEMBL19685492 0.78 1/20
SCHEMBL196142 SCHEMBL196142 0.71 1/20
SCHEMBL2398010 SCHEMBL2398010 0.71 1/20
SCHEMBL12267471 SCHEMBL12267471 0.71 1/20
SCHEMBL24863352 SCHEMBL24863352 0.69 1/20
SCHEMBL23656830 SCHEMBL23656830 0.69 1/20
SCHEMBL31060422 SCHEMBL31060422 0.68 1/20
SCHEMBL15936931 SCHEMBL15936931 0.66 1/20

Clinical trials — most relevant to ARHGEF12 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Eicosapentaenoic Acid Cerebral Vasospasm Therapy Study PHASE4COMPLETED
Simvastatin + Cetuximab/Irinotecan in K-ras Mutant Colorectal Cancer (CRC) PHASE2COMPLETED
Discovery and Validation of Genetic Variants Affecting Microglial Activation in Alzheimer's Disease PHASE2ACTIVE_NOT_RECRUITING
Interleukin-2 Treatment for Wiskott-Aldrich Syndrome PHASE1COMPLETED
ADRB3, ROCK2 and GEF Levels in Overactive Bladder Patients nanCOMPLETED
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
Identification of an Asthma Susceptibility Gene on 3P nanCOMPLETED
Study of People With Generalized Arterial Calcification of Infancy (GACI) or Autosomal Recessive Hypophosphatemic Rickets Type 2 (ARHR2) nanCOMPLETED
Genetic Characterization of Parkinson's Disease nanCOMPLETED
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma nanRECRUITING
Thrombin Regulated Platelet Activation nanCOMPLETED
NCF Gene & TNFSF4 in SLE Patients nanUNKNOWN
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED
Chromosome 5Q Gene Variants and Asthma-Related Traits nanCOMPLETED
Role of Genetic Factors in the Development of Lung Disease nanRECRUITING
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve nanUNKNOWN
Diet Intervention and GEnetic STudy (DIGEST-Pilot) nanUNKNOWN
Genetic Studies of Chronic Active Epstein-Barr Disease nanRECRUITING
Gene Analysis of Parkinson's Disease nanCOMPLETED
Molecular Markers of Human Sperm Function nanWITHDRAWN
Role of Polymorphisms in the IL-1 Gene Cluster nanCOMPLETED
Study of the Genetic and Epigenetic Causes of Recurrent Hydatidiform Moles nanACTIVE_NOT_RECRUITING
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others nanRECRUITING
CaREFREE Study (Calorie Restriction, Environment and Fitness: Reproductive Effects Evaluation Study) nanCOMPLETED
Genetic Epidemiology of Asthma in Costa Rica nanCOMPLETED
Multi-Dimensional Genomic Dissection of Ring Chromosome 14 Syndrome nanACTIVE_NOT_RECRUITING
Developing Genetic Education for Smoking Cessation nanCOMPLETED
Family Myopia Study nanCOMPLETED
Signs and Symptoms Associated With Molecular Defects in Genetically Inherited Heart Disease nanCOMPLETED
Genetics and Psychopathology in the 22q11 Deletion Syndrome nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a ARHGEF12 binder may also engage these)

ProteinNameSimilarity
A0A8I3NRY3 — 1.000 A0A8I3NRY3 →
Q8R4H2 — 1.000 Q8R4H2 →
Q9ES67 — 0.998 Q9ES67 →
O15085 — 0.996 O15085 →
Q8C0D4 — 0.993 Q8C0D4 →
O43295 — 0.993 O43295 →
Q9ULJ8 — 0.992 Q9ULJ8 →
O15013 — 0.992 O15013 →
Q91Z67 — 0.992 Q91Z67 →
Q8R0S2 — 0.992 Q8R0S2 →
A5D794 — 0.992 A5D794 →
PTPN13 Tyrosine-protein phosphatase non-receptor type 13 0.991 landscape →
A0A0G2JUG7 — 0.991 A0A0G2JUG7 →
Q80U87 — 0.991 Q80U87 →
Q8C033 — 0.991 Q8C033 →
Q5DU57 — 0.991 Q5DU57 →
Q6DN90 — 0.990 Q6DN90 →
Q1LYM3 — 0.990 Q1LYM3 →
Q6ZPS6 — 0.990 Q6ZPS6 →
Q60610 — 0.990 Q60610 →
O43150 — 0.990 O43150 →
Q9BXL7 — 0.990 Q9BXL7 →
SMARCC2 SWI/SNF complex subunit SMARCC2 0.990 landscape →
Q8IWW6 — 0.989 Q8IWW6 →
O35711 — 0.989 O35711 →
P57094 — 0.989 P57094 →
O14827 — 0.989 O14827 →
Q9D3S3 — 0.989 Q9D3S3 →
Q1LUT1 — 0.989 Q1LUT1 →
O75044 — 0.989 O75044 →