Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.84 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.84 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.84 |
| ▸ | MAPT | P10636 | 2/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.84 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.84 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.84 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.84 |
| ▸ | MEN1 | O00255 | 1/20 | 0.84 |
| ▸ | PTGES | O14684 | 1/20 | 0.84 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.84 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.84 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.84 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.84 |
| ▸ | LMNA | P02545 | 1/20 | 0.84 |
| ▸ | ALB | P02768 | 1/20 | 0.84 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.84 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.84 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31211688 | 1.00 | PTGS2 (0.84) | PTGS2PTGS1AKR1C3MAPTKMT2A | |
| SCHEMBL14886620 | 0.92 | PTGS2 (0.82) | PTGS2PTGS1AKR1C3MAPTKMT2A | |
| Indomethacin SCHEMBL29353712 | 0.91 | PTGS2 (1.00) | PTGS2PTGS1AKR1C3MAPTKMT2A | |
| Indomethacin SCHEMBL3518614 | 0.91 | PTGS2 (1.00) | PTGS2PTGS1AKR1C3MAPTKMT2A | |
| Indomethacin SCHEMBL29525957 | 0.91 | PTGS2 (1.00) | PTGS2PTGS1AKR1C3MAPTKMT2A | |
| SCHEMBL5534201 | 0.91 | PTGS2 (0.84) | PTGS2PTGS1AKR1C3MAPTKMT2A | |
| SCHEMBL15774078 | 0.91 | PTGS2 (0.84) | PTGS2PTGS1AKR1C3MAPTKMT2A | |
| SCHEMBL11563010 | 0.91 | PTGS2 (0.84) | PTGS2PTGS1AKR1C3MAPTKMT2A | |
| Indomethacin SCHEMBL9300 | 0.91 | PTGS2 (1.00) | PTGS2PTGS1AKR1C3MAPTKMT2A | |
| SCHEMBL14394799 | 0.91 | PTGS2 (0.84) | PTGS2PTGS1AKR1C3MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0047358-B1 | INDOL ACETIC DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | A. Nattermann & Cie. GmbH (DE) | 1984-09-19 | — | — | EP | claimed |
| EP-0047358-A1 | Indol acetic derivatives, process for producing the same and pharmaceutical compositions comprising the same | A. Nattermann & Cie. GmbH (DE) | 1982-03-17 | — | — | EP | claimed |
| US-20230219886-A1 | NOVEL SELENO-NSAID ANALOGS AND USES THEREOF | THE PENN STATE RESEARCH FOUNDATION | 2023-07-13 | — | — | US | disclosed |
| US-20210353579-A1 | HIGH PENETRATION COMPOSITIONS AND USES THEREOF | TECHFIELDS PHARMA CO LTD (CN) | 2021-11-18 | — | — | US | disclosed |
| US-10570161-B2 | Unique dual-action therapeutics | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2020-02-25 | — | — | US | disclosed |
| US-10450280-B2 | Tetrazolones as a carboxylic acid bioisosteres | RIGEL PHARMACEUTICALS, INC. (US) | 2019-10-22 | — | — | US | disclosed |
| EP-3250565-B1 | TETRAZOLONES AS CARBOXYLIC ACID BIOISOSTERES | RIGEL PHARMACEUTICALS INC (US) | 2019-07-03 | — | — | EP | disclosed |
| US-9872846-B2 | High penetration compositions and uses thereof | TECHFIELDS PHARMA CO., LTD. (CN) | 2018-01-23 | — | — | US | disclosed |
| US-20170209585-A1 | HIGH PENETRATION COMPOSITIONS AND USES THEREOF | TECHFIELDS PHARMA CO LTD (CN) | 2017-07-27 | — | — | US | disclosed |
| US-20170209404-A1 | HIGH PENETRATION COMPOSITIONS AND USES THEREOF | PREMIER RESEARCH INTERNATIONAL, LLC | 2017-07-27 | — | — | US | disclosed |
| US-9701647-B2 | Tetrazolones as a carboxylic acid bioisosteres | RIGEL PHARMACEUTICALS, INC. (US) | 2017-07-11 | — | — | US | disclosed |
| US-4532249-A | Derivatives of p-acylaminophenol having a therapeutic action, and compositions having a therapeutic action containing said derivatives as pharmacologically active ingredients | MOLNAR FRANCOIS (CH) | 1985-07-30 | — | — | US | disclosed |
| EP-0047358-B1 | INDOL ACETIC DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | A. Nattermann & Cie. GmbH (DE) | 1984-09-19 | — | — | EP | disclosed |
| US-4464379-A | Indol acetic acid derivatives and anti-inflamatory and related uses thereof | A. NATTERMANN & CIE GMBH (DE) | 1984-08-07 | — | — | US | disclosed |
| EP-0024282-B1 | BENZOYL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICINES | Dr. Karl Thomae GmbH (DE) | 1983-05-18 | — | — | EP | disclosed |
| US-4362738-A | ANTIINFLAMMATORIES | DR. KARL THOMAE GMBH (DE) | 1982-12-07 | — | — | US | disclosed |
| EP-0047358-A1 | Indol acetic derivatives, process for producing the same and pharmaceutical compositions comprising the same | A. Nattermann & Cie. GmbH (DE) | 1982-03-17 | — | — | EP | disclosed |
| EP-0035412-A1 | Amidotetrazole compounds and processes for their preparation | GLAXO GROUP LIMITED (GB) | 1981-09-09 | — | — | EP | disclosed |
| EP-0024282-A1 | Benzoyl derivatives, their preparation and their use as medicines | Dr. Karl Thomae GmbH (DE) | 1981-03-04 | — | — | EP | disclosed |
| US-4136194-A | ANTIINFLAMMATORY | SPOFA, UNITED PHARMACEUTICAL WORKS (CS) | 1979-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10450280-B2 | Tetrazolones as a carboxylic acid bioisosteres | GLS, CYP11B2, GLS2 | PTGS2 2794/4885PTGS1 3346/4885AKR1C3 389/4885 |
| US-20170209404-A1 | HIGH PENETRATION COMPOSITIONS AND USES THEREOF | HPGDS, PTGIS, PTGES | PTGS2 7/4885PTGS1 4/4885AKR1C3 1079/4885 |
| US-20210353579-A1 | HIGH PENETRATION COMPOSITIONS AND USES THEREOF | HPGDS, PTGIS, PTGES | PTGS2 7/4885PTGS1 4/4885AKR1C3 1079/4885 |
| US-20170209585-A1 | HIGH PENETRATION COMPOSITIONS AND USES THEREOF | HPGDS, PTGIS, PTGES | PTGS2 7/4885PTGS1 4/4885AKR1C3 1079/4885 |
| US-10570161-B2 | Unique dual-action therapeutics | ACHE, PDE1A, PDE1C | PTGS2 19/4885PTGS1 28/4885AKR1C3 272/4885 |
| US-20230219886-A1 | NOVEL SELENO-NSAID ANALOGS AND USES THEREOF | SELENOI, SCLY, GPX1 | PTGS2 14/4885PTGS1 5/4885AKR1C3 1586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.