GOLIM4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL21943538	0.59	1/20
SCHEMBL21943762	0.57	1/20
SCHEMBL21944043	0.55	1/20
SCHEMBL21943004	0.55	1/20
SCHEMBL21942995	0.53	1/20
SCHEMBL21943411	0.53	1/20
SCHEMBL14042267	0.52	1/20
SCHEMBL21943429	0.52	1/20
SCHEMBL22066328	0.51	1/20
SCHEMBL21943540	0.49	1/20
SCHEMBL21943537	0.45	1/20
SCHEMBL24532074	0.42	1/20
SCHEMBL1454562	0.42	1/20
SCHEMBL17612956	0.42	1/20
SCHEMBL12399198	0.42	1/20
SCHEMBL29911712	0.40	1/20

Clinical trials — most relevant to GOLIM4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD	PHASE3	COMPLETED
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47)	PHASE1/PHASE2	NOT_YET_RECRUITING
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)	PHASE1/PHASE2	RECRUITING
Ambroxol Therapy for Patients With Type 1 Gaucher Disease and Suboptimal Response to Enzyme Replacement Therapy	PHASE2	COMPLETED
68 Gallium-Fibroblast Activating Protein Inhibitors-46 Positron Emission Tomography - Computerized Tomography for Molecular Assessment of Fibroblast Activation and Risk Assessment in Solid Tumors	PHASE2	UNKNOWN
PBA Use for Treatment of ATF6-/- Patients	EARLY_PHASE1	SUSPENDED
Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D)	EARLY_PHASE1	COMPLETED
A Multicenter Phenotype-Genotype Analysis of LGMD Patients in China	nan	ENROLLING_BY_INVITATION
Glycosylation in Patients With Galactosaemia	nan	COMPLETED
Clinical Application of PET Imaging Targeting GPA33 in Malignant Tumors	nan	NOT_YET_RECRUITING
Genetic Investigations in Children With Developmental and Epileptic Encephalopathies in Ho Chi Minh City, Vietnam	nan	UNKNOWN
Evaluation of CEMIP in Pancreatic Cancer	nan	UNKNOWN
Clinical Trial Readiness for the Dystroglycanopathies	nan	RECRUITING
Registry Gangliosidoses	nan	UNKNOWN
Study of the Pathophysiological Mechanisms Involved in Bleeding Events	nan	COMPLETED
Genetic Studies of Lysosomal Storage Disorders	nan	ENROLLING_BY_INVITATION
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
A Clinical Study on the Safety and Efficacy of CAR-T Therapy for the TM4SF1- and EpCAM-positive Solid Tumors	nan	UNKNOWN
Neutrophils as Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis)	nan	COMPLETED
McArdle Disease Treatment by Ketogenic Diet	nan	COMPLETED
Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord Stimulation	nan	UNKNOWN
Hydroxychloroquin (HCQ) in chILD of Genetic Defect	nan	COMPLETED
Genetic Analysis of Gray Platelet Syndrome	nan	COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise	nan	COMPLETED
Biomarker for Mucolipidosis Disorder Type I, II, III, IV (BioML)	nan	WITHDRAWN
Defining Clinical Endpoints in Limb Girdle Muscular Dystrophy (LGMD)	nan	COMPLETED
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy	nan	COMPLETED
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Genetic Study of Patients With Primary Ciliary Dyskinesia	nan	COMPLETED
Genetic Analysis of Hereditary Disorders of Hearing and Balance	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GOLIM4 binder may also engage these)

Protein	Name	Similarity
Q5BJK8	—	0.997	Q5BJK8 →
Q8BXA1	—	0.996	Q8BXA1 →
Q08D19	—	0.986	Q08D19 →
Q5R5X4	—	0.983	Q5R5X4 →
Q6P4E1	—	0.979	Q6P4E1 →
Q6P2L7	—	0.979	Q6P2L7 →
Q32N32	—	0.977	Q32N32 →
Q91XA2	—	0.975	Q91XA2 →
A2VE10	—	0.974	A2VE10 →
Q5ZKQ5	—	0.974	Q5ZKQ5 →
Q8NBJ4	—	0.971	Q8NBJ4 →
Q640L3	—	0.969	Q640L3 →
P24054	—	0.966	P24054 →
Q5R6R3	—	0.965	Q5R6R3 →
Q4KLH6	—	0.964	Q4KLH6 →
Q5ZM60	—	0.964	Q5ZM60 →
Q6ZQ06	—	0.964	Q6ZQ06 →
A2VD12	—	0.963	A2VD12 →
P23499	—	0.963	P23499 →
Q9ULG6	—	0.962	Q9ULG6 →
Q3TVI8	—	0.962	Q3TVI8 →
Q06335	—	0.962	Q06335 →
Q8BVV7	—	0.961	Q8BVV7 →
Q14515	—	0.961	Q14515 →
P15943	—	0.961	P15943 →
P26339	—	0.961	P26339 →
Q91ZV0	—	0.961	Q91ZV0 →
Q06481	—	0.960	Q06481 →
P70663	—	0.960	P70663 →
Q96AQ6	—	0.960	Q96AQ6 →