Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 4/20 | 0.40 |
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.39 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.39 |
| ▸ | P2RY4 known ✓ | P51582 | 1/20 | 0.39 |
| ▸ | CA12 known ✓ | O43570 | 1/20 | 0.38 |
| ▸ | KCNH3 | Q9ULD8 | 10/20 | 0.55 |
| ▸ | RAD51 | Q06609 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | CDK4 | P11802 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CDK7 | P50613 | 2/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCNH | P51946 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL893017 | 1.00 | KCNH3 (0.55) | KCNH3RAD51NPSR1CA2CDK1 | |
| SCHEMBL29885454 | 1.00 | KCNH3 (0.55) | KCNH3RAD51NPSR1CA2CDK1 | |
| SCHEMBL30448563 | 0.90 | KCNH3 (0.57) | KCNH3NPSR1CA2CDK1KDR | |
| SCHEMBL5632031 | 0.90 | KCNH3 (0.57) | KCNH3NPSR1CA2CDK1KDR | |
| SCHEMBL793178 | 0.90 | KCNH3 (0.57) | KCNH3NPSR1CA2CDK1KDR | |
| SCHEMBL893019 | 0.89 | KCNH3 (0.56) | KCNH3NPSR1CA2CDK1KDR | |
| SCHEMBL16671688 | 0.89 | RAD51 (0.49) | KCNH3RAD51NPSR1CA2CA1 | |
| SCHEMBL10435962 | 0.87 | RAD51 (0.47) | KCNH3RAD51NPSR1CA2CA1 | |
| SCHEMBL893765 | 0.86 | RAD51 (0.60) | RAD51NPSR1CA2CA1CA9 | |
| SCHEMBL1169584 | 0.86 | RAD51 (0.60) | RAD51NPSR1CA2CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1865051-B1 | Bleaching compositions | PROCTER & GAMBLE (US) | 2019-03-20 | — | — | EP | disclosed |
| US-8501448-B2 | Family 44 xyloglucanases | NOVOZYMES A/S (DK) | 2013-08-06 | — | — | US | disclosed |
| US-20130086755-A1 | Family 44 Xyloglucanases | NOVOZYMES A/S (DK) | 2013-04-11 | — | — | US | disclosed |
| EP-2285944-B1 | LIQUID DETERGENT COMPOSITIONS | NOVOZYMES AS (DK) | 2013-03-13 | — | — | EP | disclosed |
| US-8354263-B2 | Family 44 xyloglucanases | NOVOZYMES A/S (DK) | 2013-01-15 | — | — | US | disclosed |
| US-20120289450-A1 | Cellulase Variants | NOVOZYMES A/S (DK) | 2012-11-15 | — | — | US | disclosed |
| US-20120079665-A1 | FAMILY 44 XYLOGLUCANASES | NOVOZYMES A/S (DK) | 2012-04-05 | — | — | US | disclosed |
| US-8071351-B2 | Family 44 xyloglucanases | NOVOZYMES A/S (DK) | 2011-12-06 | — | — | US | disclosed |
| US-20110250674-A1 | CELLULASE VARIANTS | NOVOZYMES A/S (DK) | 2011-10-13 | — | — | US | disclosed |
| US-8017372-B2 | Modified glucanase for use in textile and fabric treatment, detergents and papermaking | NOVOZYMES A/S (DK) | 2011-09-13 | — | — | US | disclosed |
| EP-0581752-B1 | Built dye transfer inhibiting compositions | PROCTER & GAMBLE (US) | 1998-12-09 | — | — | EP | disclosed |
| EP-0390287-B1 | Particulate detergent additive product, preparation and use thereof in detergent compositions | UNILEVER NV (NL) | 1994-03-02 | — | — | EP | disclosed |
| EP-0057088-B2 | DETERGENT COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1992-09-02 | — | — | EP | disclosed |
| EP-0085448-B2 | DETERGENT COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1990-10-10 | — | — | EP | disclosed |
| EP-0095904-B1 | DETERGENT LIQUORS AND COMPOSITIONS FOR USE THEREIN | THE PROCTER & GAMBLE COMPANY (US) | 1986-09-03 | — | — | EP | disclosed |
| EP-0057088-B1 | Detergent compositions | THE PROCTER & GAMBLE COMPANY (US) | 1985-08-21 | — | — | EP | disclosed |
| US-4502986-A | TEA AND WINE | THE PROCTER & GAMBLE COMPANY (US) | 1985-03-05 | — | — | US | disclosed |
| EP-0040038-B1 | GRANULAR DETERGENT COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1985-02-20 | — | — | EP | disclosed |
| EP-0051986-A2 | Detergent compositions | THE PROCTER & GAMBLE COMPANY (US) | 1982-05-19 | — | — | EP | disclosed |
| EP-0040038-A2 | Granular detergent compositions | THE PROCTER & GAMBLE COMPANY (US) | 1981-11-18 | — | — | EP | disclosed |