SCHEMBL701054

SCHEMBL701054

CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](OC(=O)C[C@H](N)C(=O)O)[C@H]1OC(=O)C[C@H](N)C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
LGALS8 O00214 8/20 0.56
CD209 Q9NNX6 1/20 0.44
LGALS3 P17931 7/20 0.40
LGALS4 P56470 3/20 0.40
LGALS9 O00182 1/20 0.37
LGALS1 P09382 1/20 0.37
LGALS7; LGALS7B P47929 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6129339 0.79 LGALS8 (0.52) LGALS8LGALS3LGALS4LGALS9LGALS1
SCHEMBL25339181 0.79 CD209 (0.40) LGALS8CD209
SCHEMBL17283396 0.77 LGALS8 (0.58) LGALS8LGALS3LGALS4LGALS9LGALS1
SCHEMBL10972064 0.75 LGALS3 (0.46) LGALS8LGALS3LGALS4
SCHEMBL1674815 0.75 LGALS8 (0.56) LGALS8LGALS3LGALS4LGALS9LGALS1
SCHEMBL18864321 0.74 LGALS8 (0.47) LGALS8LGALS3LGALS4LGALS9LGALS1
SCHEMBL19409216 0.73 LGALS8 (0.55) LGALS8
SCHEMBL8194583 0.73 LGALS8 (0.55) LGALS8
SCHEMBL16327733 0.72 LGALS8 (0.60) LGALS8LGALS3LGALS4LGALS9LGALS1
SCHEMBL10781121 0.71 LGALS8 (0.57) LGALS8LGALS3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3356356-B1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED (US) 2021-05-26 EP disclosed
US-10392371-B2 Compounds useful as modulators of TRPM8 SENOMYX, INC. (US) 2019-08-27 US disclosed
US-20190177308-A9 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. 2019-06-13 US disclosed
US-20180273517-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX INC (US) 2018-09-27 US disclosed
EP-3356356-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 Senomyx, Inc. (US) 2018-08-08 EP disclosed
US-9732071-B2 Compounds useful as modulators of TRPM8 SENOMYX, INC. (US) 2017-08-15 US disclosed
US-20170143022-A1 Compositions Incorporating an Umami Flavor Agent SENOMYX INC (US) 2017-05-25 US disclosed
US-20170096418-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED 2017-04-06 US disclosed
US-20170087199-A1 COMPOSITIONS FOR DELIVERING A COOLING SENSATION SENOMYX INC (US) 2017-03-30 US disclosed
US-20160376263-A1 BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF SENOMYX INC (US) 2016-12-29 US disclosed
US-20110177545-A1 G-PROTEINS GIVAUDAN SA (CH) 2011-07-21 US disclosed
US-20110097741-A1 PARTIAL T1R2 NUCLEIC ACID SEQUENCE, RECEPTOR PROTEIN AND ITS USE IN SCREENING ASSAYS GIVAUDAN SA (CH) 2011-04-28 US disclosed
US-7919236-B2 G-proteins GIVAUDAN SA (CH) 2011-04-05 US disclosed
US-20090176266-A1 FUNCTIONAL METHOD TO IDENTIFY TASTANTS GIVAUDAN S.A. (CH) 2009-07-09 US disclosed
EP-2007805-A1 NUCLEIC ACID, POLYPEPTIDE AND ITS USE Givaudan SA (CH) 2008-12-31 EP disclosed
EP-2008095-A1 FUNCTIONAL METHOD TO IDENTIFY TASTANTS Givaudan SA (CH) 2008-12-31 EP disclosed
EP-1581555-B1 CHIMERIC ALPHA Q-GUSTDUCIN G-PROTEINS GIVAUDAN SA (CH) 2008-04-30 EP disclosed
WO-2007121600-A1 NUCLEIC ACID, POLYPEPTIDE AND ITS USE GIVAUDAN SA (CH) 2007-11-01 WO disclosed
WO-2007121599-A1 FUNCTIONAL METHOD TO IDENTIFY TASTANTS GIVAUDAN SA (CH) 2007-11-01 WO disclosed
US-20060275765-A1 G-proteins GIVAUDAN SA (CH) 2006-12-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110097741-A1 PARTIAL T1R2 NUCLEIC ACID SEQUENCE, RECEPTOR PROTEIN AND ITS USE IN SCREENING ASSAYS TAS2R30, TAS1R2, TAS2R31 LGALS8 3210/4885CD209 2407/4885LGALS3 3831/4885
US-20160376263-A1 BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF TAS2R5, TAS1R1, TAS2R1 LGALS8 1379/4885CD209 1991/4885LGALS3 1516/4885
US-10392371-B2 Compounds useful as modulators of TRPM8 TRPM8, TRPM4, TRPM6 LGALS8 407/4885CD209 3929/4885LGALS3 3855/4885
US-20170143022-A1 Compositions Incorporating an Umami Flavor Agent TAS2R8, TAS2R45, TAS2R40 LGALS8 580/4885CD209 2239/4885LGALS3 2243/4885
US-20190177308-A9 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM6, TRPM4 LGALS8 435/4885CD209 4030/4885LGALS3 4060/4885
US-20180273517-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM6, TRPM4 LGALS8 435/4885CD209 4030/4885LGALS3 4060/4885
US-20170087199-A1 COMPOSITIONS FOR DELIVERING A COOLING SENSATION TRPA1, PDE6G, PDE6D LGALS8 1384/4885CD209 605/4885LGALS3 1884/4885
US-20170096418-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM6, TRPM4 LGALS8 435/4885CD209 4030/4885LGALS3 4060/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.