Sugi Predict

Sugi Predict / Compounds / SCHEMBL1230893

SCHEMBL1230893

SCHEMBL1230893

C[C@H](N)C(=O)c1cccc(CBr)c1

nearest known ligand 0.53

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ SLC7A5 Q01650 3/20 0.42
▸ ANPEP P15144 1/20 0.42
▸ ENPEP Q07075 1/20 0.42
▸ LOXL2 Q9Y4K0 1/20 0.41
▸ MEP1B Q16820 5/20 0.40
▸ CES2 O00748 1/20 0.40
▸ CES1 P23141 1/20 0.40
▸ FOLH1 Q04609 1/20 0.39
▸ MEN1 O00255 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ CYP4F2 P78329 2/20 0.38
▸ CYP4A11 Q02928 2/20 0.38
▸ MRGPRX4 Q96LA9 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL22614757 0.98 SLC7A5 (0.41) SLC7A5ANPEPENPEPLOXL2MEP1B
SCHEMBL9041418 0.85 SMYD3 (0.47) SLC7A5ANPEPENPEPLOXL2MEP1B
SCHEMBL21271291 0.83 SLC7A5 (0.42) SLC7A5ANPEPENPEPLOXL2MEP1B
Hydrochloric Acid SCHEMBL22614718 0.82 SLC7A5 (0.41) SLC7A5ANPEPENPEPLOXL2MEP1B
SCHEMBL3007585 0.79 CES2 (0.48) ANPEPENPEPLOXL2CES2CES1
Hydrochloric Acid SCHEMBL22614733 0.77 CES2 (0.47) ANPEPENPEPLOXL2CES2CES1
SCHEMBL9040971 0.77 PARP1 (0.58) MEN1KMT2A
SCHEMBL599749 0.77 MAOB (0.51) CES2CES1MEN1KMT2AMRGPRX4
SCHEMBL2108942 0.77 MEP1B (0.59) MEP1BCES2CES1FOLH1MEN1
SCHEMBL30896294 0.77 MEP1B (0.59) MEP1BCES2CES1FOLH1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3782649-B1 BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS ASCENDIS PHARMA AS (DK) 2025-05-14 — — EP disclosed
US-20230381323-A1 RELEASABLE CONJUGATES FISH & RICHARDSON PC 2023-11-30 — — US disclosed
US-11786599-B2 Releasable conjugates QUIAPEG PHARMACEUTICALS AB (SE) 2023-10-17 — — US disclosed
US-20230123784-A1 Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels ASCENDIS PHARMA A/S (DK) 2023-04-20 — — US disclosed
US-11559482-B2 Biodegradable polyethylene glycol based water-insoluble hydrogels ASCENDIS PHARMA A/S (DE) 2023-01-24 — — US disclosed
EP-4011396-A1 RELEASABLE CONJUGATES QuiaPEG Pharmaceuticals AB (SE) 2022-06-15 — — EP disclosed
EP-3592393-B1 RELEASABLE CONJUGATES QUIAPEG PHARMACEUTICALS AB (SE) 2021-12-01 — — EP disclosed
US-11116849-B2 Hydrogel-linked prodrugs releasing tagged drugs ASCENDIS PHARMA A/S (DK) 2021-09-14 — — US disclosed
EP-3782649-A1 BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS Ascendis Pharma A/S (DK) 2021-02-24 — — EP disclosed
EP-2459220-B1 BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS ASCENDIS PHARMA AS (DK) 2020-09-09 — — EP disclosed
EP-2741778-A1 POLYMERIC HYPERBRANCHED CARRIER-LINKED PRODRUGS Ascendis Pharma A/S (DK) 2014-06-18 — — EP disclosed
EP-2741779-A1 HIGH-LOADING WATER-SOLUBLE CARRIER-LINKED PRODRUGS Ascendis Pharma A/S (DK) 2014-06-18 — — EP disclosed
US-20130053301-A1 DIPEPTIDE-BASED PRODRUG LINKERS FOR ALIPHATIC AMINE-CONTAINING DRUGS ASCENDIS PHARMA A/S (DK) 2013-02-28 — — US disclosed
WO-2013024048-A1 POLYMERIC HYPERBRANCHED CARRIER-LINKED PRODRUGS ASCENDIS PHARMA A/S (DK) 2013-02-21 — — WO disclosed
WO-2013024049-A1 PROTEIN CARRIER-LINKED PRODRUGS ASCENDIS PHARMA A/S (DK) 2013-02-21 — — WO disclosed
WO-2013024047-A1 HIGH-LOADING WATER-SOLUBLE CARRIER-LINKED PRODRUGS ASCENDIS PHARMA A/S (DK) 2013-02-21 — — WO disclosed
US-20120156259-A1 Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels ASCENDIS PHARMA A/S (DK) 2012-06-21 — — US disclosed
EP-2459220-A1 BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS Ascendis Pharma A/S (DK) 2012-06-06 — — EP disclosed
WO-2011089216-A1 DIPEPTIDE-BASED PRODRUG LINKERS FOR ALIPHATIC AMINE-CONTAINING DRUGS ASCENDIS PHARMA AS (DK) 2011-07-28 — — WO disclosed
WO-2011012715-A1 BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS ASCENDIS PHARMA AS (DK) 2011-02-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120156259-A1 Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels PLG, PHYKPL, PLOD3 SLC7A5 3178/4885ANPEP 1389/4885ENPEP 489/4885
US-20130053301-A1 DIPEPTIDE-BASED PRODRUG LINKERS FOR ALIPHATIC AMINE-CONTAINING DRUGS DNPEP, PEPD, DAO SLC7A5 10/4885ANPEP 15/4885ENPEP 29/4885
US-20230123784-A1 Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels PLG, PHYKPL, PLOD3 SLC7A5 3178/4885ANPEP 1389/4885ENPEP 489/4885
US-20230381323-A1 RELEASABLE CONJUGATES GUSB, ABCB11, UGT2B7 SLC7A5 341/4885ANPEP 753/4885ENPEP 418/4885
US-11559482-B2 Biodegradable polyethylene glycol based water-insoluble hydrogels PLG, PHYKPL, PLOD3 SLC7A5 3178/4885ANPEP 1389/4885ENPEP 489/4885
US-11786599-B2 Releasable conjugates GUSB, ABCB11, UGT2B7 SLC7A5 341/4885ANPEP 753/4885ENPEP 418/4885
US-11116849-B2 Hydrogel-linked prodrugs releasing tagged drugs PTMS, PGLS, PAM SLC7A5 2406/4885ANPEP 335/4885ENPEP 186/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.