SCHEMBL2274195

SCHEMBL2274195

O=C(Nc1cc(Oc2ccccc2)ccc1C(=O)O)c1ccccc1O

nearest known ligand 0.66

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PNLIP P16233 6/20 0.66
NPC1 O15118 2/20 0.53
LMNA P02545 1/20 0.53
TP53 P04637 1/20 0.53
GAA P10253 1/20 0.53
HTT P42858 1/20 0.53
MEN1 O00255 2/20 0.52
KMT2A Q03164 2/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
MAPT P10636 1/20 0.52
RAB9A P51151 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
MAPK1 P28482 1/20 0.52
GFER P55789 1/20 0.52
STK39 Q9UEW8 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14428222 0.86 PNLIP (0.61) PNLIPNPC1LMNATP53GAA
SCHEMBL2275036 0.85 L3MBTL1 (0.64) NPC1LMNAGAAMEN1KMT2A
SCHEMBL2269563 0.85 STK39 (0.57) PNLIPHTTMEN1KMT2AL3MBTL1
SCHEMBL2268019 0.85 MAPK1 (0.57) NPC1LMNAGAAHTTMEN1
SCHEMBL2271588 0.85 SERPINE1 (0.64) NPC1MEN1KMT2AMAPTRAB9A
SCHEMBL2272800 0.84 HTT (0.52) GAAHTTMEN1KMT2AL3MBTL1
SCHEMBL1317306 0.84 MCL1 (0.54) PNLIPSTK39
SCHEMBL2270154 0.83 KMT2A (0.65) LMNAGAAMEN1KMT2AMAPT
SCHEMBL2276745 0.83 SERPINE1 (0.65) NPC1MEN1KMT2AMAPTRAB9A
SCHEMBL2271352 0.82 MAPK1 (0.57) NPC1LMNATP53GAAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 PNLIP 4862/4885NPC1 4836/4885LMNA 3235/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.