SCHEMBL1514346

SCHEMBL1514346

O=C(NC(=O)c1ccccc1Oc1ccc(Cl)cc1Cl)Nc1cc(Cl)cc(Cl)c1

nearest known ligand 0.60

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
GCGR P47871 1/20 0.60
MEN1 O00255 2/20 0.59
RAB9A P51151 2/20 0.59
KMT2A Q03164 2/20 0.59
NPC1 O15118 1/20 0.59
ATM Q13315 1/20 0.59
STK39 Q9UEW8 3/20 0.51
PNLIP P16233 6/20 0.49
PYGL P06737 4/20 0.49
CHRM1 P11229 1/20 0.46
MAPT P10636 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
S1PR1 P21453 1/20 0.45
DHODH Q02127 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8661386 0.80 GCGR (0.87) GCGRRAB9ANPC1STK39PNLIP
SCHEMBL11036755 0.79 RAB9A (0.60) GCGRMEN1RAB9AKMT2ANPC1
SCHEMBL8660806 0.77 GCGR (0.61) GCGRMEN1RAB9AKMT2ANPC1
SCHEMBL10746567 0.77 PYGL (0.64) GCGRRAB9ANPC1STK39PNLIP
SCHEMBL641133 0.75 HPGD (0.62) CHRM1MAPT
SCHEMBL8660867 0.74 PNLIP (0.53) GCGRMEN1RAB9AKMT2ANPC1
SCHEMBL4150117 0.74 CHRM1 (0.57) MEN1KMT2ASTK39CHRM1MAPT
SCHEMBL8657550 0.73 GCGR (0.57) GCGRMEN1RAB9AKMT2ANPC1
SCHEMBL8657049 0.73 GCGR (0.59) GCGRMEN1RAB9AKMT2ANPC1
SCHEMBL11388824 0.73 GCGR (0.62) GCGRMEN1RAB9AKMT2ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7902144-B2 Carrier-molecule-affinitive substance which has an association constant KA relative to a carrier molecule greater than 103 M-1 via a noncovalent bond KTB TUMORFORSCHUNGSGESELLSCHAFT MBH (DE) 2011-03-08 US disclosed
US-20030185793-A1 Therapeutic and diagnostic ligand systems comprising transport molecule binding properties and medicaments containing the same Vergell Medical S.A. (CH) 2003-10-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030185793-A1 Therapeutic and diagnostic ligand systems comprising transport molecule binding properties and medicaments containing the same SLCO1B1, SLCO1B3, SLCO1A2 GCGR 1213/4885MEN1 1538/4885RAB9A 3897/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.