SCHEMBL776364

SCHEMBL776364

CCNc1c(C)cc(C)cc1C

nearest known ligand 0.55

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 11/20 0.55
TSHR P16473 2/20 0.43
CYP3A4 P08684 1/20 0.43
RECQL P46063 1/20 0.43
FFAR4 Q5NUL3 1/20 0.42
LMNA P02545 1/20 0.41
ALDH1A1 P00352 1/20 0.40
HPGD P15428 1/20 0.40
NLRP3 Q96P20 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL27516695 0.97 RAPGEF4 (0.52) RAPGEF4TSHRCYP3A4RECQLFFAR4
SCHEMBL14002878 0.85 FFAR4 (0.47) RAPGEF4TSHRCYP3A4RECQLFFAR4
SCHEMBL24348160 0.84 RAPGEF4 (0.52) RAPGEF4TSHRCYP3A4RECQLFFAR4
SCHEMBL8294250 0.84 TSHR (0.56) RAPGEF4TSHRLMNAALDH1A1HPGD
SCHEMBL12909372 0.84 RAPGEF4 (0.44) RAPGEF4TSHRCYP3A4RECQLFFAR4
SCHEMBL2756366 0.81 RAPGEF4 (0.57) RAPGEF4CYP3A4FFAR4LMNAALDH1A1
SCHEMBL12963494 0.80 RAPGEF4 (0.50) RAPGEF4TSHRFFAR4LMNAALDH1A1
SCHEMBL12852100 0.80 ALDH1A1 (0.43) RAPGEF4TSHRCYP3A4RECQLALDH1A1
SCHEMBL8285137 0.80 TAAR1 (0.40) TSHRCYP3A4RECQLFFAR4
SCHEMBL13073787 0.78 METAP2 (0.53) RAPGEF4TSHRLMNAALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200369689-A1 Arylaminosilane Compound, Propylene Polymerization Catalyst And Preparation Thereof PETROCHINA COMPANY LIMITED (CN) 2020-11-26 US claimed
CN-111978346-A Arylamine silane compound, propylene polymerization catalyst, preparation and application thereof 中国石油天然气股份有限公司 2020-11-24 CN claimed
US-11655371-B2 Color material dispersion liquid, color resin composition, color filter, liquid crystal display device, and light-emitting display device DAI NIPPON PRINTING CO., LTD. (JP) 2023-05-23 US disclosed
US-11535638-B2 Arylaminosilane compound, propylene polymerization catalyst and preparation thereof PETROCHINA COMPANY LIMITED (CN) 2022-12-27 US disclosed
WO-2022087121-A1 MULTIDENTATE LEWIS BASE CATALYSTS AND METHODS FOR USE THEREOF EXXONMOBIL CHEMICAL PATENTS INC. (US) 2022-04-28 WO disclosed
CN-109415298-B Compounds and intermediates thereof 大日本印刷株式会社 2022-03-29 CN disclosed
US-20210324200-A1 COLOR MATERIAL DISPERSION LIQUID, COLOR RESIN COMPOSITION, COLOR FILTER, LIQUID CRYSTAL DISPLAY DEVICE, AND LIGHT-EMITTING DISPLAY DEVICE DAI NIPPON PRINTING CO., LTD. (JP) 2021-10-21 US disclosed
WO-2021188361-A1 LINEAR ALPHA-OLEFIN COPOLYMERS AND IMPACT COPOLYMERS THEREOF EXXONMOBIL CHEMICAL PATENTS INC. (US) 2021-09-23 WO disclosed
WO-2021162745-A1 PROPYLENE COPOLYMERS OBTAINED USING TRANSITION METAL BIS(PHENOLATE) CATALYST COMPLEXES AND HOMOGENEOUS PROCESS FOR PRODUCTION THEREOF EXXONMOBIL CHEMICAL PATENTS INC. (US) 2021-08-19 WO disclosed
US-11084934-B2 Color material dispersion liquid, color resin composition, color filter, liquid crystal display device, and light-emitting display device DAI NIPPON PRINTING CO., LTD. (JP) 2021-08-10 US disclosed
WO-2021034459-A1 ISOTACTIC PROPYLENE HOMOPOLYMERS AND COPOLYMERS PRODUCED WITH C1 SYMMETRIC METALLOCENE CATALYSTS EXXONMOBIL CHEMICAL PATENTS INC. (US) 2021-02-25 WO disclosed
US-20070093502-A1 5- Or 6-substituted benzimidazole derivatives as inhibitors of respiratory syncytial virus replication BONFANTI JEAN-FRANCOIS 2007-04-26 US disclosed
US-20070093502-A1 5- Or 6-substituted benzimidazole derivatives as inhibitors of respiratory syncytial virus replication BONFANTI JEAN-FRANCOIS 2007-04-26 US disclosed
EP-1725562-A1 PYRROLOPYRIMIDINE DERIVATIVES TAISHO PHARMACEUTICAL CO., LTD (JP) 2006-11-29 EP disclosed
CN-1265881-C High activity metal carbene metathesis catalysts prepared using thermally activated N-heterocyclic carbene precursors CALIFORNIA INST OF TECHN (US) 2006-07-26 CN disclosed
WO-2005085253-A1 PYRROLOPYRIMIDINE DERIVATIVES TAISHO PHARMACEUTICAL CO., LTD. (JP) 2005-09-15 WO disclosed
WO-2005058874-A1 5- OR 6-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION TIBOTEC PHARMACEUTICALS LTD. (IE) 2005-06-30 WO disclosed
CN-1511064-A High activity metal carbene metathesis catalysts prepared using thermally activated N-heterocyclic carbene precursors ����ʯ��ѧԺ 2004-07-07 CN disclosed
WO-2003024448-A2 INHIBITORS OF HISTONE DEACETYLASE METHYLGENE, INC. (CA) 2003-03-27 WO disclosed
WO-1995006642-A1 MALODINITRIL-SUBSTITUTED 1,3,5-TRIAZIN-DIAMINES WITH HERBICIDAL ACTIVITY BAYER AKTIENGESELLSCHAFT (DE) 1995-03-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11535638-B2 Arylaminosilane compound, propylene polymerization catalyst and preparation thereof RPS8, PARP8, PRMT8 RAPGEF4 668/4885TSHR 912/4885CYP3A4 1230/4885
US-20070093502-A1 5- Or 6-substituted benzimidazole derivatives as inhibitors of respiratory syncytial virus replication H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, SUB1, HYOU1 RAPGEF4 4220/4885TSHR 2810/4885CYP3A4 1242/4885
US-20200369689-A1 Arylaminosilane Compound, Propylene Polymerization Catalyst And Preparation Thereof RPS8, PARP8, PRMT8 RAPGEF4 668/4885TSHR 912/4885CYP3A4 1230/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.