Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 12/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8690078 | 0.83 | TSHR (0.64) | VCAM1TDP1TSHRMAPK1HSD17B10 | |
| SCHEMBL6840900 | 0.80 | TSHR (0.56) | TDP1TSHRMAPK1HSD17B10 | |
| SCHEMBL7721899 | 0.79 | VCAM1 (0.59) | VCAM1NPBWR1MCHR1 | |
| SCHEMBL1665978 | 0.78 | PARP1 (0.56) | TDP1TSHRMAPK1 | |
| SCHEMBL14371934 | 0.78 | MAPT (0.43) | TDP1TSHRMAPK1HSD17B10 | |
| SCHEMBL358730 | 0.78 | MAPK1 (0.69) | VCAM1TDP1TSHRMAPK1 | |
| SCHEMBL29394047 | 0.78 | MAPK1 (0.69) | VCAM1TDP1TSHRMAPK1 | |
| SCHEMBL5992360 | 0.78 | VCAM1 (0.60) | VCAM1TDP1TSHRMAPK1 | |
| Dinitrochlorobenzene SCHEMBL20472381 | 0.77 | HSD17B10 (0.69) | VCAM1TDP1TSHRMAPK1HSD17B10 | |
| Dinitrochlorobenzene SCHEMBL39251 | 0.77 | HSD17B10 (0.69) | VCAM1TDP1TSHRMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2892873-A1 | PROCESS FOR PREPARING 6-IODO-2-OXINDOLE | Boehringer Ingelheim International GmbH (DE) | 2015-07-15 | — | — | EP | claimed |
| US-8975418-B2 | Process for preparing 6-iodo-2-oxindole | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-03-10 | — | — | US | claimed |
| WO-2014037307-A1 | PROCESS FOR PREPARING 6-IODO-2-OXINDOLE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-03-13 | — | — | WO | claimed |
| US-20140066634-A1 | PROCESS FOR PREPARING 6-IODO-2-OXINDOLE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-03-06 | — | — | US | claimed |
| CN-107513020-B | A kind of synthetic method of m-iodonitrobenzene compound | NANCHANG UNIVERSITY (CN) | 2019-10-29 | — | — | CN | disclosed |
| CN-107513020-A | A kind of synthetic method of m-iodonitrobenzene compound | 南昌大学 | 2017-12-26 | — | — | CN | disclosed |
| EP-3072882-A1 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR THE PRODUCTION AND USE THEREOF | Alla Chem, LLC. (US) | 2016-09-28 | — | — | EP | disclosed |
| US-9249138-B2 | Anti-viral compounds | ABBVIE INC. (US) | 2016-02-02 | — | — | US | disclosed |
| EP-2892873-A1 | PROCESS FOR PREPARING 6-IODO-2-OXINDOLE | Boehringer Ingelheim International GmbH (DE) | 2015-07-15 | — | — | EP | disclosed |
| US-20150152086-A1 | Insecticidal Aryl Pyrrolidines | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-06-04 | — | — | US | disclosed |
| US-8980937-B2 | Insecticidal aryl pyrrolidines | BAYER CROPSCIENCE AG (DE) | 2015-03-17 | — | — | US | disclosed |
| US-8975418-B2 | Process for preparing 6-iodo-2-oxindole | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-03-10 | — | — | US | disclosed |
| WO-2008128711-A1 | INSECTICIDAL ARYL PYRROLIDINES | BAYER CROPSCIENCE AG (DE) | 2008-10-30 | — | — | WO | disclosed |
| US-7381728-B2 | Piperazine derivatives useful for the treatment of gastrointestinal disorders | GLAXO GROUP LIMITED (GB) | 2008-06-03 | — | — | US | disclosed |
| WO-2008008375-A2 | TRIAZOLYL PYRIDYL BENZENESULFONAMIDES AS CCR2 OR CCR9 MODULATORS FOR THE TREATMENT OF INFLAMMATION | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |
| US-20070259877-A1 | Piperazine Derivatives Useful for the Treatment of Gastrointestinal Disorders | GLAXO GROUP LIMITED | 2007-11-08 | — | — | US | disclosed |
| EP-1778679-A1 | PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006010629-A1 | PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-02-02 | — | — | WO | disclosed |
| US-4684731-A | NEUROLEPTIC, ANTIEMETIC, ANALGESIC | HOFFMANN-LA ROCHE INC. (US) | 1987-08-04 | — | — | US | disclosed |
| US-4391978-A | NEUROLEPTIC AGENTS, ANTIEMETICS, ANALGESICS | HOFFMANN-LA ROCHE INC. (US) | 1983-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152086-A1 | Insecticidal Aryl Pyrrolidines | DDT, ITPR3, CYP51A1 | VCAM1 4829/4885TDP1 3839/4885TSHR 846/4885 |
| US-20070259877-A1 | Piperazine Derivatives Useful for the Treatment of Gastrointestinal Disorders | GHSR, GHRHR, GIPR | VCAM1 4733/4885TDP1 4871/4885TSHR 26/4885 |
| US-20140066634-A1 | PROCESS FOR PREPARING 6-IODO-2-OXINDOLE | INTS6, IP6K2, CYP2D6 | VCAM1 4679/4885TDP1 3674/4885TSHR 900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.