SCHEMBL10014130

SCHEMBL10014130

COc1ccc(C(=O)c2cccc(C(=O)c3ccc(Oc4ccc(C(=O)c5ccc(C)cc5)cc4)cc3)c2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
STS P08842 2/20 0.56
ALDH1A1 P00352 2/20 0.55
GAA P10253 1/20 0.55
MMP13 P45452 2/20 0.53
CTSL P07711 1/20 0.52
LMNA P02545 2/20 0.51
RAB9A P51151 2/20 0.51
MEN1 O00255 1/20 0.51
MAPT P10636 1/20 0.51
MAPK1 P28482 1/20 0.51
KMT2A Q03164 1/20 0.51
NPSR1 Q6W5P4 1/20 0.51
RXFP1 Q9HBX9 1/20 0.51
PARP10 Q53GL7 1/20 0.51
HPGD P15428 1/20 0.51
TUBB4A P04350 1/20 0.50
TUBB P07437 1/20 0.50
TUBA3C P0DPH7 1/20 0.50
TUBA1B P68363 1/20 0.50
TUBA4A P68366 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10014132 1.00 STS (0.56) STSALDH1A1GAAMMP13CTSL
SCHEMBL13026416 1.00 STS (0.56) STSALDH1A1GAAMMP13CTSL
SCHEMBL19353003 0.96 STS (0.52) STSALDH1A1GAAMMP13CTSL
SCHEMBL16948014 0.96 STS (0.52) STSALDH1A1GAAMMP13CTSL
SCHEMBL12276577 0.95 STS (0.60) STSALDH1A1GAACTSLLMNA
SCHEMBL12299803 0.94 STS (0.60) STSMMP13RAB9AMEN1MAPT
SCHEMBL19726407 0.94 ALDH1A1 (0.57) STSALDH1A1MMP13LMNARAB9A
SCHEMBL27399132 0.94 ALDH1A1 (0.62) STSALDH1A1GAACTSLLMNA
SCHEMBL13026427 0.93 MMP13 (0.56) STSMMP13RAB9AMEN1KMT2A
SCHEMBL14030885 0.91 MMP13 (0.56) STSALDH1A1GAAMMP13LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10023692-B2 Method for the manufacture of poly(aryl ether ketone)s in the presence of sodium carbonate SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2018-07-17 US disclosed
US-10023692-B2 Method for the manufacture of poly(aryl ether ketone)s in the presence of sodium carbonate SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2018-07-17 US disclosed
US-9815937-B2 Process for preparing a poly(aryl ether ketone) using a high purity 4,4′-difluorobenzophenone SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2017-11-14 US disclosed
US-9815937-B2 Process for preparing a poly(aryl ether ketone) using a high purity 4,4′-difluorobenzophenone SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2017-11-14 US disclosed
EP-2588513-B1 METHOD OF MAKING POLY(ARYL ETHER KETONES) FROM 4,4' DIFLUOROBENZOPHENONE COMPRISING OXIDIZING SPECIES AND/OR NITRO COMPOUNDS SOLVAY SPECIALTY POLYMERS USA (US) 2017-10-04 EP disclosed
US-9765185-B2 High purity diphenyl sulfone, preparation and use thereof for the preparation of a poly(aryletherketone) SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2017-09-19 US disclosed
US-9765185-B2 High purity diphenyl sulfone, preparation and use thereof for the preparation of a poly(aryletherketone) SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2017-09-19 US disclosed
US-20160145386-A1 PROCESS FOR PREPARING A POLY(ARYL ETHER KETONE) USING A HIGH PURITY 4,4'- DIFLUOROBENZOPHENONE SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2016-05-26 US disclosed
US-20160145385-A1 METHOD FOR THE MANUFACTURE OF POLY(ARYL ETHER KETONE)S IN THE PRESENCE OF SODIUM CARBONATE SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2016-05-26 US disclosed
US-20160145385-A1 METHOD FOR THE MANUFACTURE OF POLY(ARYL ETHER KETONE)S IN THE PRESENCE OF SODIUM CARBONATE SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2016-05-26 US disclosed
US-20110213095-A1 Method for the manufacture of poly(aryl ether ketone)s in the presence of sodium carbonate SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2011-09-01 US disclosed
US-20110213095-A1 Method for the manufacture of poly(aryl ether ketone)s in the presence of sodium carbonate SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2011-09-01 US disclosed
US-20110213115-A1 Process for preparing a poly(aryl ether ketone) using a high purity 4,4'-difluorobenzophenone SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2011-09-01 US disclosed
US-20110201775-A1 High purity diphenyl sulfone, preparation and use thereof for the preparation of a poly(aryletherketone) SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2011-08-18 US disclosed
US-20110201775-A1 High purity diphenyl sulfone, preparation and use thereof for the preparation of a poly(aryletherketone) SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2011-08-18 US disclosed
WO-2010046484-A1 METHOD FOR THE MANUFACTURE OF POLY(ARYL ETHER KETONE)S IN THE PRESENCE OF SODIUM CARBONATE SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2010-04-29 WO disclosed
WO-2010046483-A1 IMPROVED PROCESS FOR PREPARING A POLY(ARYL ETHER KETONE) USING A HIGH PURITY 4,4'-DIFLUOROBENZOPHENONE SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2010-04-29 WO disclosed
WO-2010046487-A1 IMPROVED METHOD FOR THE MANUFACTURE OF POLY(ARYL ETHER KETONE)S AND IMPROVED METHOD FOR PROVIDING A SODIUM CARBONATE SUITABLE FOR THE MANUFACTURE OF POLY(ARYL ETHER KETONE)S SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2010-04-29 WO disclosed
WO-2010046482-A1 HIGH PURITY DIPHENYL SULFONE, PREPARATION AND USE THEREOF FOR THE PREPARATION OF A POLY(ARYLETHERKETONE) SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2010-04-29 WO disclosed
WO-2009021918-A1 IMPROVED POLY(ARYLETHERKETONE)S AND PROCESS FOR MAKING THEM SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2009-02-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10023692-B2 Method for the manufacture of poly(aryl ether ketone)s in the presence of sodium carbonate PKM, KCNK10, KCNK9 STS 374/4885ALDH1A1 3084/4885GAA 2358/4885
US-20110201775-A1 High purity diphenyl sulfone, preparation and use thereof for the preparation of a poly(aryletherketone) DHPS, PKM, PCBP1 STS 26/4885ALDH1A1 1626/4885GAA 413/4885
US-20160145386-A1 PROCESS FOR PREPARING A POLY(ARYL ETHER KETONE) USING A HIGH PURITY 4,4'- DIFLUOROBENZOPHENONE HNF4A, CUL4B, CUL4A STS 3299/4885ALDH1A1 1653/4885GAA 3270/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.