Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 2/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.36 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22219382 | 0.89 | NISCH (0.42) | NISCHAKR1C3AKR1C2HDAC1HDAC6 | |
| SCHEMBL14365641 | 0.88 | NISCH (0.45) | NISCHAKR1C3AKR1C2KMOERN1 | |
| SCHEMBL13087002 | 0.87 | NISCH (0.43) | NISCHAKR1C3AKR1C2HDAC1HDAC6 | |
| SCHEMBL17407511 | 0.83 | ESR1 (0.56) | NISCHAKR1C3AKR1C2HDAC1HDAC6 | |
| SCHEMBL10014272 | 0.83 | NFE2L2 (0.48) | AKR1C3AKR1C2ESR1ESR2DHODH | |
| SCHEMBL24540157 | 0.82 | AKR1C3 (0.38) | NISCHAKR1C3AKR1C2HDAC1HDAC6 | |
| SCHEMBL19807356 | 0.82 | PTGS2 (0.48) | KMODHODHPTGS2PTGS1 | |
| SCHEMBL12377626 | 0.81 | NISCH (0.52) | NISCHAKR1C3AKR1C2HDAC1HDAC6 | |
| SCHEMBL91695 | 0.80 | ERN1 (0.47) | NISCHAKR1C3AKR1C2KMOERN1 | |
| SCHEMBL10304803 | 0.80 | NISCH (0.44) | NISCHAKR1C3AKR1C2HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11834599-B2 | Aromatic isothiocyanates | MERCK PATENT GMBH (DE) | 2023-12-05 | — | — | US | disclosed |
| US-11739265-B2 | Aromatic isothiocyanates | MERCK PATENT GMBH (DE) | 2023-08-29 | — | — | US | disclosed |
| US-11667841-B2 | Dibenzofuran and dibenzothiophene derivatives | MERCK PATENT GMBH (DE) | 2023-06-06 | — | — | US | disclosed |
| US-11312908-B2 | Liquid crystal medium and liquid crystal display | MERCK PATENT GMBH (DE) | 2022-04-26 | — | — | US | disclosed |
| US-11268026-B2 | Liquid-crystalline medium | MERCK PATENT GMBH (DE) | 2022-03-08 | — | — | US | disclosed |
| US-20210403810-A1 | DIBENZOFURAN AND DIBENZOTHIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2021-12-30 | — | — | US | disclosed |
| US-11208594-B2 | Liquid-crystalline medium and high-frequency components comprising same | MERCK PATENT GMBH (DE) | 2021-12-28 | — | — | US | disclosed |
| US-20210115337-A1 | LIQUID-CRYSTALLINE MEDIUM | MERCK PATENT GMBH (DE) | 2021-04-22 | — | — | US | disclosed |
| US-20210102122-A1 | LIQUID CRYSTAL MEDIUM | MERCK PATENT GMBH (DE) | 2021-04-08 | — | — | US | disclosed |
| US-10711197-B2 | Liquid-crystalline medium and high-frequency components comprising same | MERCK PATENT GMBH (DE) | 2020-07-14 | — | — | US | disclosed |
| EP-1816180-B1 | Mesogenic compounds, liquid crystal medium, and liquid crystal display | MERCK PATENT GMBH (DE) | 2008-10-29 | — | — | EP | disclosed |
| EP-1690917-B1 | Mesogenic compounds, liquid crystal medium and liquid crystal display | MERCK PATENT GMBH (DE) | 2008-10-08 | — | — | EP | disclosed |
| US-20080167482-A1 | mesogenic group is linked to the C-atom No. 5 of the 1,3-dioxane-5-yl group; media showing a blue phase and their use in electro-optical light modulation elements | MERCK PATENT GMBH (DE) | 2008-07-10 | — | — | US | disclosed |
| US-20080167482-A1 | mesogenic group is linked to the C-atom No. 5 of the 1,3-dioxane-5-yl group; media showing a blue phase and their use in electro-optical light modulation elements | MERCK PATENT GMBH (DE) | 2008-07-10 | — | — | US | disclosed |
| US-20080116419-A1 | Mesogenic Compounds, Liquid Crystal Medium and Liquid Crystal Display | MERCK PATENT GMBH (DE) | 2008-05-22 | — | — | US | disclosed |
| US-20080116419-A1 | Mesogenic Compounds, Liquid Crystal Medium and Liquid Crystal Display | MERCK PATENT GMBH (DE) | 2008-05-22 | — | — | US | disclosed |
| EP-1690915-B1 | Mesogenic compounds, liquid crystal medium and liquid crystal display | MERCK PATENT GMBH (DE) | 2008-03-26 | — | — | EP | disclosed |
| EP-1690916-B1 | Mesogenic compounds, liquid crystal medium and liquid crystal display | MERCK PATENT GMBH (DE) | 2008-03-12 | — | — | EP | disclosed |
| EP-1816180-A1 | Mesogenic compounds, liquid crystal medium, and liquid crystal display | Merck Patent GmbH (DE) | 2007-08-08 | — | — | EP | disclosed |
| EP-1739151-A1 | Mesogenic compounds, liquid crystal medium and liquid display | MERCK PATENT GmbH (DE) | 2007-01-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11667841-B2 | Dibenzofuran and dibenzothiophene derivatives | DDT, MYT1, DBF4 | NISCH 196/4885AKR1C3 4097/4885AKR1C2 4331/4885 |
| US-20210403810-A1 | DIBENZOFURAN AND DIBENZOTHIOPHENE DERIVATIVES | DDT, MYT1, DBF4 | NISCH 196/4885AKR1C3 4097/4885AKR1C2 4331/4885 |
| US-20080116419-A1 | Mesogenic Compounds, Liquid Crystal Medium and Liquid Crystal Display | CRY1, CRY2, IK | NISCH 126/4885AKR1C3 2896/4885AKR1C2 3229/4885 |
| US-11739265-B2 | Aromatic isothiocyanates | TRPA1, CRY1, FOXM1 | NISCH 202/4885AKR1C3 3786/4885AKR1C2 3646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.