Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | XBP1 | P17861 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | TERT | O14746 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.31 |
| ▸ | TAS2R46 | P59540 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tomentosin SCHEMBL29422245 | 0.82 | KDR (0.58) | KDRMAPTRAB9APKMRECQL | |
| SCHEMBL29367155 | 0.68 | KDR (0.52) | KDRMAPTRAB9APKMRECQL | |
| SCHEMBL30366249 | 0.62 | NLRP3 (0.41) | MAPTRAB9APKMRECQLPTGS2 | |
| Carabrol SCHEMBL30932148 | 0.62 | PTGS2 (0.39) | MAPTRAB9APKMRECQLNPC1 | |
| SCHEMBL8629540 | 0.59 | MAPT (0.43) | KDRMAPTRAB9APKMRECQL | |
| SCHEMBL9242953 | 0.59 | MAPT (0.43) | KDRMAPTRAB9APKMRECQL | |
| SCHEMBL8631899 | 0.59 | MAPT (0.43) | KDRMAPTRAB9APKMRECQL | |
| SCHEMBL29410309 | 0.59 | MAPT (0.43) | KDRMAPTRAB9APKMRECQL | |
| SCHEMBL29665914 | 0.57 | TAS2R46 (0.56) | KDRMAPTRAB9APKMRECQL | |
| SCHEMBL31238361 | 0.55 | MAPT (0.51) | KDRMAPTRAB9APKMRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040916-A1 | MOLECULAR INHIBITORS OF THE WNT/BETA-CATENIN PATHWAY | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-02-16 | — | — | US | disclosed |
| US-20120040916-A1 | MOLECULAR INHIBITORS OF THE WNT/BETA-CATENIN PATHWAY | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-02-16 | — | — | US | disclosed |
| WO-2010075282-A1 | MOLECULAR INHIBITORS OF THE WNT/BETA-CATENIN PATHWAY | UNIVERSITY OF WASHINGTON (US) | 2010-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040916-A1 | MOLECULAR INHIBITORS OF THE WNT/BETA-CATENIN PATHWAY | WNT1, CTNNB1, WNT3A | KDR 4401/4885MAPT 1720/4885RAB9A 1578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.