SCHEMBL10028781

SCHEMBL10028781

CN(C)C(=O)c1cc(Cl)cc(Cl)c1NC(=O)c1cc(Cl)nn1-c1ncccc1Cl

nearest known ligand 0.56

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ NTRK1 P04629 1/20 0.35
▸ PTGS1 P23219 1/20 0.35
▸ F10 P00742 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ CNR2 P34972 1/20 0.34
▸ DHODH Q02127 2/20 0.34
▸ MALT1 Q9UDY8 3/20 0.33
▸ CNR1 P21554 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ RBP4 P02753 1/20 0.33
▸ TRPV1 Q8NER1 1/20 0.33
▸ CXCR2 P25025 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13998590 0.91 F10 (0.43) NTRK1F10KMT2AMEN1
SCHEMBL13998637 0.91 ALDH1A1 (0.33) NTRK1KMT2ADHODHMALT1MEN1
SCHEMBL10028783 0.91 DHODH (0.41) NTRK1PTGS1F10KMT2ACNR2
SCHEMBL11893200 0.89 DHODH (0.37) KMT2ADHODHMALT1MEN1RBP4
SCHEMBL782242 0.88 MALT1 (0.38) NTRK1KMT2ADHODHMALT1RBP4
SCHEMBL10028786 0.88 F10 (0.39) F10KMT2AMEN1TRPV1
SCHEMBL10028779 0.86 ALDH1A1 (0.37) NTRK1F10KMT2ADHODHMALT1
SCHEMBL10028759 0.86 CHIA (0.40) NTRK1KMT2ACNR2CNR1MEN1
SCHEMBL782499 0.86 CNR1 (0.36) KMT2ACNR2DHODHMALT1CNR1
SCHEMBL12528144 0.85 F10 (0.42) F10KMT2ADHODHMALT1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1699290-B2 INSECTICIDAL ACTIVE SUBSTANCE COMBINATIONS CONTAINING ANTHRANILIC ACID AMIDES AND AT LEAST ONE OTHER INSECTICIDE BAYER CROPSCIENCE AG (DE) 2015-04-15 — — EP disclosed
EP-1691608-B2 ACTIVE SUBSTANCE COMBINATION HAVING INSECTICIDAL AND ACARICIDAL PROPERTIES BAYER CROPSCIENCE AG (DE) 2015-04-08 — — EP disclosed
US-8993483-B2 Combination of active substances with insecticidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-03-31 — — US disclosed
US-8993483-B2 Combination of active substances with insecticidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-03-31 — — US disclosed
US-8865683-B2 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AG (DE) 2014-10-21 — — US disclosed
US-8865683-B2 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AG (DE) 2014-10-21 — — US disclosed
US-8821898-B2 Active compound combinations having insecticidal and acaricidal properties BAYER CROPSCIENCE AG (DE) 2014-09-02 — — US disclosed
US-8821898-B2 Active compound combinations having insecticidal and acaricidal properties BAYER CROPSCIENCE AG (DE) 2014-09-02 — — US disclosed
US-8778895-B2 Active agent combinations with insecticidal and acaricidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-07-15 — — US disclosed
US-8778895-B2 Active agent combinations with insecticidal and acaricidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-07-15 — — US disclosed
US-20080070863-A1 Combination Of Active Substances With Insecticidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2008-03-20 — — US disclosed
US-20080070863-A1 Combination Of Active Substances With Insecticidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2008-03-20 — — US disclosed
US-20080027114-A1 Active Agent Combinations with Insecticidal and Acaricidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2008-01-31 — — US disclosed
US-20080027114-A1 Active Agent Combinations with Insecticidal and Acaricidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2008-01-31 — — US disclosed
US-20070270416-A1 Active Compound Combinations Having Insecticidal and Acaricidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-11-22 — — US disclosed
US-20070270416-A1 Active Compound Combinations Having Insecticidal and Acaricidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-11-22 — — US disclosed
US-20070232598-A1 Combination of Active Substances with Insecticidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-10-04 — — US disclosed
US-20070232598-A1 Combination of Active Substances with Insecticidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-10-04 — — US disclosed
US-20070142327-A1 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-06-21 — — US disclosed
US-20070142327-A1 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-06-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070142327-A1 Active compound combinations having insecticidal properties ACHE, ANTXR2, NANP NTRK1 4461/4885PTGS1 2570/4885F10 1682/4885
US-20080027114-A1 Active Agent Combinations with Insecticidal and Acaricidal Properties AADAC, ACAA2, AAAS NTRK1 4548/4885PTGS1 3043/4885F10 1524/4885
US-20080070863-A1 Combination Of Active Substances With Insecticidal Properties AADAC, ANTXR2, ACHE NTRK1 3699/4885PTGS1 2015/4885F10 1276/4885
US-20070232598-A1 Combination of Active Substances with Insecticidal Properties ACHE, CHRM3, CHRNA2 NTRK1 1175/4885PTGS1 3124/4885F10 2739/4885
US-20070270416-A1 Active Compound Combinations Having Insecticidal and Acaricidal Properties AADAC, ACAA2, AAAS NTRK1 4584/4885PTGS1 2874/4885F10 1398/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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