Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5708457 | 0.96 | KDM4E (0.58) | KDM4EPOLBALDH1A1RECQLRXFP1 | |
| Water SCHEMBL1048309 | 0.94 | KDM4E (0.57) | KDM4EPOLBALDH1A1RECQLRXFP1 | |
| SCHEMBL4177550 | 0.86 | KDM4E (0.66) | KDM4EPOLBALDH1A1RECQLRXFP1 | |
| SCHEMBL13645489 | 0.85 | KDM4E (0.64) | KDM4EPOLBRECQLHTTMAPT | |
| SCHEMBL13686278 | 0.83 | KDM4E (0.62) | KDM4EPOLBRECQLBCHEACHE | |
| SCHEMBL19749239 | 0.82 | KDM4E (0.71) | KDM4EPOLBALDH1A1RECQLRXFP1 | |
| SCHEMBL19485776 | 0.79 | KDM4E (0.61) | KDM4EPOLBALDH1A1RECQLHTT | |
| SCHEMBL16450366 | 0.79 | KDM4E (0.57) | KDM4EPOLBALDH1A1RECQLHTT | |
| SCHEMBL15419914 | 0.79 | KDM4E (0.79) | KDM4EPOLBALDH1A1RECQLHTT | |
| Bromide SCHEMBL5394060 | 0.78 | KDM4E (0.64) | KDM4EPOLBALDH1A1RECQLHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10011570-B2 | Nucleic acid binding dyes with improved safety | BIOTIUM, INC. (US) | 2018-07-03 | — | — | US | disclosed |
| US-9636424-B2 | Composition, method, system and kit for optical electrophysiology | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2017-05-02 | — | — | US | disclosed |
| US-20160256576-A1 | COMPOSITION, METHOD, SYSTEM AND KIT FOR OPTICAL ELECTROPHYSIOLOGY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-09-08 | — | — | US | disclosed |
| EP-2607431-B1 | Cyanine dye compounds | LIFE TECHNOLOGIES CORP (US) | 2016-08-24 | — | — | EP | disclosed |
| US-9382425-B2 | Aza-benzazolium containing cyanine dyes | Life Technologies Corporation (US) | 2016-07-05 | — | — | US | disclosed |
| US-9357924-B2 | Composition, method, system and kit for optical electrophysiology | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2016-06-07 | — | — | US | disclosed |
| US-20150185182-A1 | NUCLEIC ACID BINDING DYES WITH IMPROVED SAFETY | BIOTIUM, INC. | 2015-07-02 | — | — | US | disclosed |
| US-20150185182-A1 | NUCLEIC ACID BINDING DYES WITH IMPROVED SAFETY | BIOTIUM, INC. | 2015-07-02 | — | — | US | disclosed |
| US-20150031579-A1 | Aza-Benzazolium Containing Cyanine Dyes | MOLECULAR PROBES, INC. | 2015-01-29 | — | — | US | disclosed |
| US-8883415-B2 | Aza-benzazolium containing cyanine dyes | Life Technologies Corporation (US) | 2014-11-11 | — | — | US | disclosed |
| US-20080044811-A1 | nucleic acid or a poly(amino acid) samples and dyes in form of staining solution are combined for sufficient time to form dye-analyte complex and are illuminated with an appropriate wavelength whereby nucleic acid or a poly(amino acid) is detected | INVITROGEN CORPORATION (US) | 2008-02-21 | — | — | US | disclosed |
| WO-2008015415-A2 | ASYMMETRIC FLUORO-SUBSTITUTED POLYMETHINE DYES | GE HEALTHCARE AS (NO) | 2008-02-07 | — | — | WO | disclosed |
| US-7226740-B2 | nucleic acid or a poly(amino acid) samples and dyes in form of staining solution are combined for sufficient time to form dye-analyte complex and are illuminated with an appropriate wavelength whereby nucleic acid or a poly(amino acid) is detected | INVITROGEN CORPORATION (US) | 2007-06-05 | — | — | US | disclosed |
| EP-1720944-A2 | CYANINE DYE COMPOUNDS | Molecular Probes Inc. (US) | 2006-11-15 | — | — | EP | disclosed |
| US-20050214810-A1 | Cyanine dye compounds | MOLECULAR PROBES, INC. | 2005-09-29 | — | — | US | disclosed |
| WO-2005056689-A2 | CYANINE DYE COMPOUNDS | MOLECULAR PROBES, INC. (US) | 2005-06-23 | — | — | WO | disclosed |
| US-20040137475-A1 | nucleic acid or a poly(amino acid) samples and dyes in form of staining solution are combined for sufficient time to form dye-analyte complex and are illuminated with an appropriate wavelength whereby nucleic acid or a poly(amino acid) is detected | Life Technologies Corporation | 2004-07-15 | — | — | US | disclosed |
| US-6664047-B1 | Assymetrical; substituted by a cationic side chain; exhibit bright fluorescence when associated with nucleic acid polymers such as DNA or RNA, or with polypeptides | MOLECULAR PROBES, INC. | 2003-12-16 | — | — | US | disclosed |
| US-6579718-B1 | For detecting and quantifying peptides, polypeptides and proteins; sensitive, facile and does not require use of organic solvents | MOLECULAR PROBES, INC. | 2003-06-17 | — | — | US | disclosed |
| US-4677053-A | INFRARED SENSITIZING DYE; IMPROVED SHELF LIFE | YUJI MIHARA (JP) | 1987-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040137475-A1 | nucleic acid or a poly(amino acid) samples and dyes in form of staining solution are combined for sufficient time to form dye-analyte complex and are illuminated with an appropriate wavelength whereby nucleic acid or a poly(amino acid) is detected | POLL, IK, ADAR | KDM4E 1578/4885POLB 117/4885ALDH1A1 3853/4885 |
| US-20150185182-A1 | NUCLEIC ACID BINDING DYES WITH IMPROVED SAFETY | POLRMT, POLI, EWSR1 | KDM4E 3940/4885POLB 7/4885ALDH1A1 1200/4885 |
| US-20050214810-A1 | Cyanine dye compounds | POLL, XPA, DUT | KDM4E 801/4885POLB 65/4885ALDH1A1 2751/4885 |
| US-20160256576-A1 | COMPOSITION, METHOD, SYSTEM AND KIT FOR OPTICAL ELECTROPHYSIOLOGY | KCNN3, KCNN2, KCNN1 | KDM4E 2585/4885POLB 3817/4885ALDH1A1 1454/4885 |
| US-10011570-B2 | Nucleic acid binding dyes with improved safety | POLRMT, POLI, EWSR1 | KDM4E 3940/4885POLB 7/4885ALDH1A1 1200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.