Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | RECQL | P46063 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | IDE | P14735 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5708457 | 0.99 | KDM4E (0.58) | KDM4EPOLBALDH1A1RECQLRXFP1 | |
| SCHEMBL1002934 | 0.94 | KDM4E (0.57) | KDM4EPOLBALDH1A1RECQLRXFP1 | |
| SCHEMBL19749239 | 0.84 | KDM4E (0.71) | KDM4EPOLBALDH1A1RECQLRXFP1 | |
| SCHEMBL13645489 | 0.82 | KDM4E (0.64) | KDM4EPOLBRECQLMAPTHTT | |
| SCHEMBL4177550 | 0.81 | KDM4E (0.66) | KDM4EPOLBALDH1A1RECQLRXFP1 | |
| SCHEMBL13686278 | 0.80 | KDM4E (0.62) | KDM4EPOLBRECQL | |
| SCHEMBL19485776 | 0.79 | KDM4E (0.61) | KDM4EPOLBALDH1A1RECQLMAPT | |
| Bromide SCHEMBL5394060 | 0.78 | KDM4E (0.64) | KDM4EPOLBALDH1A1RECQLMAPT | |
| Iodide SCHEMBL6263617 | 0.78 | KDM4E (0.60) | KDM4EPOLBALDH1A1RECQLMAPT | |
| SCHEMBL12201138 | 0.77 | KDM4E (0.59) | KDM4EPOLBALDH1A1RECQLMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034125-B2 | Dye composition comprising at least one colorless disulfide/thiol precursor, and dyeing process using the composition | L'OREAL S.A. (FR) | 2011-10-11 | — | — | US | claimed |
| EP-2205681-B1 | DYE COMPOSITION COMPRISING AT LEAST ONE COLORLESS DISULFIDE/THIOL PRECURSOR, AND DYEING PROCESS USING THE COMPOSITION | OREAL (FR) | 2011-08-31 | — | — | EP | claimed |
| US-20110016642-A1 | DYE COMPOSITION COMPRISING AT LEAST ONE COLORLESS DISULFIDE/THIOL PRECURSOR, AND DYEING PROCESS USING THE COMPOSITION | L'OREAL S.A. (FR) | 2011-01-27 | — | — | US | claimed |
| EP-2205681-A1 | DYE COMPOSITION COMPRISING AT LEAST ONE COLORLESS DISULFIDE/THIOL PRECURSOR, AND DYEING PROCESS USING THE COMPOSITION | L'Oreal (FR) | 2010-07-14 | — | — | EP | claimed |
| WO-2009040354-A1 | DYE COMPOSITION COMPRISING AT LEAST ONE COLORLESS DISULFIDE/THIOL PRECURSOR, AND DYEING PROCESS USING THE COMPOSITION | L'OREAL (FR) | 2009-04-02 | — | — | WO | claimed |
| EP-1235549-B1 | AGENT FOR COLOURING KERATIN CONTAINING FIBRES | HENKEL KGAA (DE) | 2006-11-29 | — | — | EP | claimed |
| EP-1432394-A1 | AGENT FOR COLORING KERATIN FIBERS | Henkel Kommanditgesellschaft auf Aktien (DE) | 2004-06-30 | — | — | EP | claimed |
| WO-2003030846-A1 | AGENT FOR COLORING KERATIN FIBERS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2003-04-17 | — | — | WO | claimed |
| EP-1235549-A1 | AGENT FOR COLOURING KERATIN CONTAINING FIBRES | Henkel Kommanditgesellschaft auf Aktien (DE) | 2002-09-04 | — | — | EP | claimed |
| WO-2001034106-A1 | AGENT FOR COLOURING KERATIN CONTAINING FIBRES | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2001-05-17 | — | — | WO | claimed |
| US-8034125-B2 | Dye composition comprising at least one colorless disulfide/thiol precursor, and dyeing process using the composition | L'OREAL S.A. (FR) | 2011-10-11 | — | — | US | disclosed |
| EP-2205681-B1 | DYE COMPOSITION COMPRISING AT LEAST ONE COLORLESS DISULFIDE/THIOL PRECURSOR, AND DYEING PROCESS USING THE COMPOSITION | OREAL (FR) | 2011-08-31 | — | — | EP | disclosed |
| US-20110016642-A1 | DYE COMPOSITION COMPRISING AT LEAST ONE COLORLESS DISULFIDE/THIOL PRECURSOR, AND DYEING PROCESS USING THE COMPOSITION | L'OREAL S.A. (FR) | 2011-01-27 | — | — | US | disclosed |
| EP-2205681-A1 | DYE COMPOSITION COMPRISING AT LEAST ONE COLORLESS DISULFIDE/THIOL PRECURSOR, AND DYEING PROCESS USING THE COMPOSITION | L'Oreal (FR) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009040354-A1 | DYE COMPOSITION COMPRISING AT LEAST ONE COLORLESS DISULFIDE/THIOL PRECURSOR, AND DYEING PROCESS USING THE COMPOSITION | L'OREAL (FR) | 2009-04-02 | — | — | WO | disclosed |
| US-20050262647-A1 | Agent for dyeing fibers containing keratin | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) | 2005-12-01 | — | — | US | disclosed |
| US-6790239-B1 | COMBINATION OF AROMATIC ALDEHYDES OR KETONES AND CH-ACTIVE COMPOUNDS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2004-09-14 | — | — | US | disclosed |
| EP-1432394-A1 | AGENT FOR COLORING KERATIN FIBERS | Henkel Kommanditgesellschaft auf Aktien (DE) | 2004-06-30 | — | — | EP | disclosed |
| US-20040031108-A1 | Hair dyeing agents containing indigo derivatives | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) | 2004-02-19 | — | — | US | disclosed |
| WO-2003030846-A1 | AGENT FOR COLORING KERATIN FIBERS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2003-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110016642-A1 | DYE COMPOSITION COMPRISING AT LEAST ONE COLORLESS DISULFIDE/THIOL PRECURSOR, AND DYEING PROCESS USING THE COMPOSITION | KRT18, SQOR, TST | KDM4E 1460/4885POLB 1082/4885ALDH1A1 743/4885 |
| US-20040031108-A1 | Hair dyeing agents containing indigo derivatives | KRT18, BBOX1, BRDT | KDM4E 2249/4885POLB 288/4885ALDH1A1 635/4885 |
| US-20050262647-A1 | Agent for dyeing fibers containing keratin | KRT18, CKAP4, KRTCAP2 | KDM4E 1076/4885POLB 1213/4885ALDH1A1 240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.