SCHEMBL1003006

SCHEMBL1003006

OB(c1ccc(F)cc1)c1ccc(F)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TRPV6 Q9H1D0 6/20 1.00
ORAI1 Q96D31 5/20 1.00
ORAI2 Q96SN7 5/20 1.00
ORAI3 Q9BRQ5 5/20 1.00
PCSK9 Q8NBP7 1/20 0.50
CA1 P00915 3/20 0.42
CA2 P00918 3/20 0.42
CES2 O00748 1/20 0.39
CES1 P23141 1/20 0.39
CA7 P43166 1/20 0.38
CA9 Q16790 1/20 0.38
ACHE P22303 1/20 0.38
ENPP2 Q13822 1/20 0.35
SLC22A2 O15244 1/20 0.35
SLC22A1 O15245 1/20 0.35
SLC22A3 O75751 1/20 0.35
PLAU P00749 1/20 0.35
MGLL Q99685 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4833078 0.87 TRPV6 (0.76) TRPV6ORAI1ORAI2ORAI3PCSK9
SCHEMBL23219856 0.83 TRPV6 (0.70) TRPV6ORAI1ORAI2ORAI3PCSK9
SCHEMBL5164042 0.82 ORAI1 (0.67) TRPV6ORAI1ORAI2ORAI3CA1
SCHEMBL5508 0.81 ORAI1 (0.68) TRPV6ORAI1ORAI2ORAI3CA1
SCHEMBL21979751 0.81 ORAI1 (0.68) TRPV6ORAI1ORAI2ORAI3CA1
SCHEMBL16653115 0.80 TRPV6 (0.67) TRPV6ORAI1ORAI2ORAI3PCSK9
SCHEMBL18839425 0.79 ORAI1 (0.65) TRPV6ORAI1ORAI2ORAI3CA1
SCHEMBL1138738 0.79 ORAI1 (0.65) TRPV6ORAI1ORAI2ORAI3CA1
SCHEMBL5167645 0.77 TRPV6 (0.59) TRPV6ORAI1ORAI2ORAI3PCSK9
SCHEMBL2551749 0.75 CA2 (0.61) TRPV6ORAI1ORAI2ORAI3CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3521358-B1 USE OF A CROSSLINKABLE COMPOUND RUBBER COMPOSITION FOR THE COLD RETREADING OF A TYRE CONTINENTAL REIFEN DEUTSCHLAND GMBH (DE) 2021-11-10 EP claimed
EP-3541634-B1 TIRE COMPRISING A TREAD COMPRISING A THERMOPLASTIC ELASTOMER AND A CROSSLINKING SYSTEM BASED ON SULFUR MICHELIN & CIE (FR) 2020-12-30 EP claimed
EP-3521358-A1 COMPOUND RUBBER COMPOSITION AND METHOD FOR PREPARING A CROSSLINKABLE COMPOUND RUBBER COMPOSITION, AND USE OF THE COMPOUND RUBBER COMPOSITION Continental Reifen Deutschland GmbH (DE) 2019-08-07 EP claimed
EP-2978803-B1 PROCESS FOR CROSSLINKING EPM AND EPDM AKZO NOBEL CHEMICALS INT BV (NL) 2017-05-03 EP claimed
EP-0695780-B2 Rubber composition free of carcinogenic nitrosamine precursors and suitable as joining material MICHELIN & CIE (FR) 2006-12-27 EP claimed
EP-0695780-B1 Rubber composition free of carcinogenic nitrosamine precursors and suitable as joining material MICHELIN & CIE (FR) 2000-10-25 EP claimed
EP-0690091-B1 Improvements in and relating to the reclaiming of natural and synthetic rubbers SEKHAR B C SDN BHD (MY) 1999-09-15 EP claimed
US-5591726-A Heterocyclylalkyl diarylboron ester and thioester fungicidal agents AMERICAN CYANAMID COMPANY (US) 1997-01-07 US claimed
US-20260050210-A1 RESIST COMPOSITION AND METHOD FOR PRODUCING SAME NIPPON SHOKUBAI CO., LTD. (JP) 2026-02-19 US disclosed
EP-3521358-B1 USE OF A CROSSLINKABLE COMPOUND RUBBER COMPOSITION FOR THE COLD RETREADING OF A TYRE CONTINENTAL REIFEN DEUTSCHLAND GMBH (DE) 2021-11-10 EP disclosed
EP-2451767-B1 METHOD FOR PRODUCING (2,4-DIMETHYLBIPHENYL-3-YL) ACETIC ACIDS, ESTERS THEREOF AND INTERCONNECTIONS BAYER CROPSCIENCE AG (DE) 2019-08-21 EP disclosed
EP-3521358-A1 COMPOUND RUBBER COMPOSITION AND METHOD FOR PREPARING A CROSSLINKABLE COMPOUND RUBBER COMPOSITION, AND USE OF THE COMPOUND RUBBER COMPOSITION Continental Reifen Deutschland GmbH (DE) 2019-08-07 EP disclosed
US-8664428-B2 Method for producing (2,4-dimethylbiphenyl-3-yl)acetic acids, the esters thereof and intermediate compounds BAYER CROPSCIENCE AG (DE) 2014-03-04 US disclosed
EP-2451767-A2 METHOD FOR PRODUCING (2,4-DIMETHYLBIPHENYL-3-YL)ACETIC ACIDS, THE ESTERS THEREOF AND INTERMEDIATE COMPOUNDS Bayer CropScience AG (DE) 2012-05-16 EP disclosed
EP-1003753-B1 COMPOUNDS CONTAINING BORON AND ALUMINIUM BASELL POLYOLEFINE GMBH (DE) 2003-03-05 EP disclosed
US-6417302-B1 REACTION PRODUCT OF DI(PENTAFLUOROPHENYL) BORINIC ACID AND ORGANOALUMINUM COMPOUND; OLEFIN POLYMERIZATION COORDINATION CATALYSTS BASELL POLYOLEFINE GMBH (DE) 2002-07-09 US disclosed
WO-2002044184-A2 DNA METHYL TRANSFERASE INHIBITORS THE PENN STATE RESEARCH FOUNDATION (US) 2002-06-06 WO disclosed
EP-1142869-A2 Process for the preparation of zinc dithiocarbamates BAYER AG (DE) 2001-10-10 EP disclosed
US-5591726-A Heterocyclylalkyl diarylboron ester and thioester fungicidal agents AMERICAN CYANAMID COMPANY (US) 1997-01-07 US disclosed
EP-0703235-A2 Heterocyclylalkyl diarylboron ester and thioester fungicidal agents AMERICAN CYANAMID COMPANY (US) 1996-03-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260050210-A1 RESIST COMPOSITION AND METHOD FOR PRODUCING SAME MAL2, MCM6, MCM3 TRPV6 2089/4885ORAI1 505/4885ORAI2 712/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.