Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4914439 | 0.87 | TAAR1 (0.41) | RIPK1TAAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL16634021 | 0.87 | TAAR1 (0.41) | RIPK1TAAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10098880 | 0.85 | RIPK1 (0.36) | HRH1RIPK1SLC6A3ALDH1A1SMN1; SMN2 | |
| SCHEMBL8391322 | 0.84 | TRPA1 (0.40) | RIPK1SLC6A2SLC6A4SLC6A3SMN1; SMN2 | |
| SCHEMBL27032153 | 0.84 | TRPA1 (0.40) | RIPK1SLC6A2SLC6A4SLC6A3SMN1; SMN2 | |
| SCHEMBL14564989 | 0.84 | TRPA1 (0.40) | RIPK1SLC6A2SLC6A4SLC6A3SMN1; SMN2 | |
| SCHEMBL25283840 | 0.83 | RIPK1 (0.37) | RIPK1SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL25283839 | 0.83 | RIPK1 (0.37) | RIPK1SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL25288593 | 0.83 | RIPK1 (0.37) | RIPK1SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL12333567 | 0.82 | RIPK1 (0.32) | RIPK1ALDH1A1SMN1; SMN2CYP3A4HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110130349-A1 | Compounds and Methods for Treating Toll-Like Receptor 2-Related Diseases and Conditions | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-06-02 | — | — | US | disclosed |
| US-7863271-B2 | 2-aminobenzoxazole carboxamides as 5HT3 modulators | ALBANY MOLECULAR RESEARCH, INC. (US) | 2011-01-04 | — | — | US | disclosed |
| US-7550501-B2 | Compounds and methods for treating toll-like receptor 2-related diseases and conditions | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-23 | — | — | US | disclosed |
| US-20080255114-A1 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | AMR TECHNOLOGY, INC. (US) | 2008-10-16 | — | — | US | disclosed |
| US-20070167409-A1 | Compounds and Methods for Treating Toll-Like Receptor 2-Related Diseases and Conditions | EISAI CO., LTD. (JP) | 2007-07-19 | — | — | US | disclosed |
| US-7202234-B2 | Compounds and methods for treating Toll-like receptor 2-related diseases and conditions | EISAI CO., LTD. (JP) | 2007-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255114-A1 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | HTR3E, HTR3C, HTR3A | HRH1 405/4885RIPK1 4007/4885TAAR1 1071/4885 |
| US-20070167409-A1 | Compounds and Methods for Treating Toll-Like Receptor 2-Related Diseases and Conditions | TLR2, TLR6, TLR3 | HRH1 556/4885RIPK1 1011/4885TAAR1 613/4885 |
| US-20110130349-A1 | Compounds and Methods for Treating Toll-Like Receptor 2-Related Diseases and Conditions | TLR2, TLR6, TLR3 | HRH1 556/4885RIPK1 1011/4885TAAR1 613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.