Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.37 |
| ▸ | F9 | P00740 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28856400 | 0.81 | LIMK1 (0.39) | ENPP1RETFLT1KDRMAPK14 | |
| SCHEMBL20067062 | 0.80 | TLR8 (0.46) | TLR8TLR7LIMK1LOXL2MAPT | |
| SCHEMBL900791 | 0.78 | ALOX5 (0.43) | TLR8TLR7ENPP1RETFLT1 | |
| SCHEMBL28215029 | 0.76 | APP (0.45) | ENPP1RETFLT1KDRMAPK14 | |
| SCHEMBL21462955 | 0.76 | TLR8 (0.40) | TLR8TLR7LOXL2MAPTRAB9A | |
| SCHEMBL10030524 | 0.76 | ALDH1A1 (0.58) | TLR8TLR7MAPTRAB9AL3MBTL1 | |
| SCHEMBL9307538 | 0.75 | LIPG (0.37) | ENPP1RETFLT1KDRMAPK14 | |
| SCHEMBL8092634 | 0.75 | ALDH1A1 (0.51) | ENPP1RETFLT1KDRMAPK14 | |
| SCHEMBL16004771 | 0.75 | RET (0.47) | ENPP1RETFLT1KDRMAPK14 | |
| SCHEMBL1772204 | 0.75 | RET (0.41) | ENPP1RETFLT1KDRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815927-B2 | Bivalent diazo bicyclic Smac mimetics and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-08-26 | — | — | US | disclosed |
| US-20120263675-A1 | BIVALENT DIAZO BICYCLIC SMAC | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-10-18 | — | — | US | disclosed |
| US-20120009141-A1 | FUNCTIONALIZED PYRROLIDINES AND USE THEREOF AS IAP INHIBITORS | PHARMASCIENCE INC. (CA) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120009141-A1 | FUNCTIONALIZED PYRROLIDINES AND USE THEREOF AS IAP INHIBITORS | BIRC5, BIRC7, BIRC2 | TLR8 3989/4885TLR7 3296/4885ENPP1 1931/4885 |
| US-20120263675-A1 | BIVALENT DIAZO BICYCLIC SMAC | BIRC2, BID, BIRC3 | TLR8 4314/4885TLR7 3898/4885ENPP1 2142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.