Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KAT7 | O95251 | 8/20 | 0.46 |
| ▸ | KAT6A | Q92794 | 8/20 | 0.46 |
| ▸ | KAT6B | Q8WYB5 | 5/20 | 0.46 |
| ▸ | KAT5 | Q92993 | 4/20 | 0.46 |
| ▸ | KAT8 | Q9H7Z6 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10066968 | 0.84 | KMT2A (0.56) | MEN1KMT2AMAPTALDH1A1NPSR1 | |
| SCHEMBL4345848 | 0.82 | KMT2A (0.54) | MEN1KMT2AMAPTALDH1A1NPSR1 | |
| SCHEMBL10022368 | 0.82 | L3MBTL1 (0.49) | MEN1KMT2AMAPTALDH1A1NPSR1 | |
| SCHEMBL28853149 | 0.81 | ADRB2 (0.54) | MEN1KMT2AMAPTALDH1A1NPSR1 | |
| SCHEMBL12340791 | 0.80 | KLKB1 (0.45) | MEN1KMT2AMAPTHTTKAT7 | |
| SCHEMBL4354266 | 0.80 | HTT (0.56) | MEN1KMT2AMAPTALDH1A1NPSR1 | |
| SCHEMBL8815508 | 0.77 | KLKB1 (0.44) | MEN1KMT2AMAPTNPSR1HTT | |
| SCHEMBL29008820 | 0.77 | KDM4E (0.52) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL31172576 | 0.77 | HTR2A (0.46) | MEN1KMT2AMAPTALDH1A1NPSR1 | |
| SCHEMBL4857301 | 0.75 | PDE4B (0.55) | MEN1KMT2AMAPTALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590950-B1 | N-CYCLYL-3-(CYCLYLCARBONYLAMINOMETHYL)BENZAMIDE DERIVATIVES AS RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2014-10-15 | — | — | EP | disclosed |
| US-20120165322-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | US | disclosed |
| WO-2012006203-A1 | N-CYCLYL-3 - (CYCLYLCARBONYLAMINOMETHYL) BENZAMIDE DERIVATIVES AS RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165322-A1 | RHO KINASE INHIBITORS | ROCK1, ROCK2, RHOA | MEN1 1338/4885KMT2A 3143/4885MAPT 797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.