SCHEMBL10060147

SCHEMBL10060147

CN1COCN(Cc2cnc(Cl)s2)/C1=N/N=O

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.40
ALDH1A1 P00352 2/20 0.40
GAA P10253 1/20 0.40
KMT2A Q03164 2/20 0.38
RECQL P46063 1/20 0.38
MAPT P10636 2/20 0.33
MEN1 O00255 1/20 0.33
L3MBTL1 Q9Y468 3/20 0.32
TDP1 Q9NUW8 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
POLB P06746 1/20 0.32
RAB9A P51151 1/20 0.32
ATM Q13315 1/20 0.32
PARG Q86W56 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12808261 0.89
SCHEMBL14647649 0.85 LMNA (0.37) LMNAALDH1A1GAAKMT2ARECQL
Thiamethoxam SCHEMBL22918 0.84 LMNA (0.38) LMNAALDH1A1GAAKMT2ARECQL
Thiamethoxam SCHEMBL22917 0.84 LMNA (0.38) LMNAALDH1A1GAAKMT2ARECQL
Thiamethoxam SCHEMBL3956094 0.84 LMNA (0.38) LMNAALDH1A1GAAKMT2ARECQL
Thiamethoxam SCHEMBL22916 0.84 LMNA (0.38) LMNAALDH1A1GAAKMT2ARECQL
Thiamethoxam SCHEMBL25297105 0.83 LMNA (0.37) LMNAALDH1A1GAAKMT2ARECQL
Thiamethoxam SCHEMBL23393339 0.83 LMNA (0.37) LMNAALDH1A1GAAKMT2ARECQL
Thiamethoxam SCHEMBL23393337 0.83 LMNA (0.37) LMNAALDH1A1GAAKMT2ARECQL
Thiamethoxam SCHEMBL28560129 0.83 LMNA (0.37) LMNAALDH1A1GAAKMT2ARECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11744247-B2 Dermal compositions NEOGEN CORPORATION (US) 2023-09-05 US disclosed
US-20200245622-A1 DERMAL COMPOSITIONS CAP INNOVET, INC. (US) 2020-08-06 US disclosed
EP-3480196-A1 PROCESS FOR THE PREPARATION OF THIAMETHOXAM Jiangsu Rotam Chemistry Co., Ltd (CN) 2019-05-08 EP disclosed
US-8097603-B2 Compositions for controlling parasites on animals BAYER ANIMAL HEALTH GMBH (DE) 2012-01-17 US disclosed
US-20110086848-A1 Agrochemical Compositions Comprising Alkyl Polypropylene Glycol Polyethylene Glycol BAYER CROPSCIENCE AG (DE) 2011-04-14 US disclosed
US-20100311677-A1 Active Ingredient Combinations Having Insecticidal and Acaricidal Properties BAYER CROPSCIENCE AG (DE) 2010-12-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200245622-A1 DERMAL COMPOSITIONS DDT, PRNP, CUTA LMNA 1872/4885ALDH1A1 2369/4885GAA 4769/4885
US-20110086848-A1 Agrochemical Compositions Comprising Alkyl Polypropylene Glycol Polyethylene Glycol STOM, PGLS, NAPEPLD LMNA 2074/4885ALDH1A1 3121/4885GAA 748/4885
US-20100311677-A1 Active Ingredient Combinations Having Insecticidal and Acaricidal Properties ACHE, ACAT2, ACAT1 LMNA 2893/4885ALDH1A1 502/4885GAA 60/4885
US-11744247-B2 Dermal compositions DDT, PRNP, CUTA LMNA 1872/4885ALDH1A1 2369/4885GAA 4769/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.