Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TASP1 | Q9H6P5 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.62 |
| ▸ | MAPT | P10636 | 11/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.62 |
| ▸ | MEN1 | O00255 | 9/20 | 0.62 |
| ▸ | LMNA | P02545 | 7/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.62 |
| ▸ | HTT | P42858 | 5/20 | 0.62 |
| ▸ | GAA | P10253 | 5/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | F10 | P00742 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10481440 | 0.76 | TASP1 (0.61) | TASP1MAPTKMT2AMEN1LMNA | |
| SCHEMBL1347532 | 0.74 | ALDH1A1 (0.62) | TASP1ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL5180828 | 0.74 | MAPT (0.61) | TASP1ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL14096502 | 0.74 | ALDH1A1 (0.72) | TASP1ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL16553806 | 0.73 | MAPT (0.66) | TASP1ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL1346518 | 0.73 | ALDH1A1 (0.75) | TASP1ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL28640537 | 0.72 | ALDH1A1 (0.80) | ALDH1A1MAPTKMT2AMEN1LMNA | |
| SCHEMBL13956784 | 0.72 | PRSS12 (0.64) | TASP1ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL13806864 | 0.71 | HDAC1 (0.66) | TASP1ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL5935569 | 0.71 | MAPT (0.79) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501811-B2 | TASPASE1 inhibitors and their uses | WASHINGTON UNIVERSITY (US) | 2013-08-06 | — | — | US | disclosed |
| US-20120015990-A1 | TASPASE1 INHIBITORS AND THEIR USES | THE WASHINGTON UNIVERSITY (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015990-A1 | TASPASE1 INHIBITORS AND THEIR USES | RNASE1, TASP1, PPA1 | TASP1 2/4885ALDH1A1 3123/4885MAPT 4457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.