Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 2/20 | 0.52 |
| ▸ | BACE1 | P56817 | 2/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 3/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.42 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709213 | 0.80 | SCN9A (0.58) | SCN9AACHEBACE1NAMPTCYP3A4 | |
| SCHEMBL10072406 | 0.79 | SCN9A (0.57) | SCN9AACHEBACE1NAMPTCYP3A4 | |
| SCHEMBL10071963 | 0.78 | SCN9A (0.56) | SCN9AACHEBACE1FAAHNAMPT | |
| SCHEMBL1709232 | 0.73 | SCN9A (1.00) | SCN9AACHEBACE1NAMPTCYP3A4 | |
| SCHEMBL19567897 | 0.72 | OPRM1 (0.45) | LTA4HFAAHMCHR1CCR5CYP3A4 | |
| SCHEMBL18860348 | 0.71 | NAMPT (0.48) | SCN9ANAMPT | |
| SCHEMBL1709211 | 0.71 | SCN9A (0.59) | SCN9AACHEBACE1NAMPT | |
| SCHEMBL1709247 | 0.71 | SCN9A (0.64) | SCN9ANAMPTCYP3A4 | |
| SCHEMBL1709234 | 0.70 | SCN9A (0.60) | SCN9AACHEBACE1NAMPTCYP3A4 | |
| SCHEMBL381873 | 0.70 | OPRL1 (0.75) | MMP2MMP9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |