Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.57 |
| ▸ | NAMPT | P43490 | 3/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.39 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10071963 | 0.90 | SCN9A (0.56) | SCN9ANAMPTACHEBACE1CYP3A4 | |
| SCHEMBL1709213 | 0.82 | SCN9A (0.58) | SCN9ANAMPTACHEBACE1CYP3A4 | |
| SCHEMBL10071962 | 0.79 | SCN9A (0.57) | SCN9ANAMPTACHEBACE1CYP3A4 | |
| SCHEMBL18860348 | 0.78 | NAMPT (0.48) | SCN9ANAMPTKCNH2SIGMAR1 | |
| SCHEMBL1709247 | 0.73 | SCN9A (0.64) | SCN9ANAMPTCYP3A4SIGMAR1MEN1 | |
| SCHEMBL1709211 | 0.73 | SCN9A (0.59) | SCN9ANAMPTACHEBACE1SIGMAR1 | |
| SCHEMBL1709232 | 0.73 | SCN9A (1.00) | SCN9ANAMPTACHEBACE1CYP3A4 | |
| SCHEMBL1709234 | 0.73 | SCN9A (0.60) | SCN9ANAMPTACHEBACE1CYP3A4 | |
| SCHEMBL9566388 | 0.69 | CXCR4 (0.53) | SCN9ANAMPTACHEBACE1CYP3A4 | |
| SCHEMBL29424020 | 0.67 | CHRM4 (0.73) | SCN9AACHECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |