Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 3/20 | 0.46 |
| ▸ | GLO1 | Q04760 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709247 | 0.76 | SCN9A (0.64) | SCN9AMEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL1709232 | 0.75 | SCN9A (1.00) | SCN9AMEN1KMT2ACYP3A4NAMPT | |
| SCHEMBL10072406 | 0.73 | SCN9A (0.57) | SCN9AMEN1KMT2ACYP3A4CYP2C19 | |
| SCHEMBL10071963 | 0.72 | SCN9A (0.56) | SCN9AMEN1KMT2ACYP3A4NAMPT | |
| SCHEMBL1709211 | 0.72 | SCN9A (0.59) | SCN9AMEN1KMT2ANAMPTHTT | |
| SCHEMBL1709213 | 0.71 | SCN9A (0.58) | SCN9ACYP3A4NAMPTKDM4EALDH1A1 | |
| SCHEMBL10071962 | 0.70 | SCN9A (0.57) | SCN9ACYP3A4NAMPTACHEBACE1 | |
| SCHEMBL8053546 | 0.69 | HDAC6 (0.64) | MEN1KMT2ARECQLGLO1HTT | |
| SCHEMBL18753515 | 0.67 | NPC1 (0.51) | MEN1KMT2AMAPK1HTTSMN1; SMN2 | |
| SCHEMBL6637562 | 0.67 | DRD2 (0.61) | MEN1KMT2ACYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |