SCHEMBL10080214

SCHEMBL10080214

O=C1c2ccccc2NC2C=CC=CC12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.41
LMNA P02545 1/20 0.41
TNKS2 Q9H2K2 6/20 0.37
PBRM1 Q86U86 1/20 0.37
MAOA P21397 1/20 0.34
MAOB P27338 1/20 0.34
PDGFRA P16234 1/20 0.34
FER P16591 1/20 0.34
LTK P29376 1/20 0.34
CDK8 P49336 1/20 0.34
ACVR1 Q04771 1/20 0.34
LRRK2 Q5S007 1/20 0.34
DYRK1B Q9Y463 1/20 0.34
ALDH1A1 P00352 4/20 0.33
HPGD P15428 3/20 0.33
HSD17B10 Q99714 3/20 0.33
KMT2A Q03164 3/20 0.33
KDM4E B2RXH2 2/20 0.33
MEN1 O00255 2/20 0.33
TTK P33981 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13294620 0.84 LMNA (0.32) TSHRLMNA
SCHEMBL12333958 0.78 TNKS2 (0.37) TSHRTNKS2PBRM1ALDH1A1HPGD
SCHEMBL19398067 0.76 NPC1 (0.33) TSHRLMNAALDH1A1HPGDHSD17B10
SCHEMBL29689764 0.75 KMT2A (0.50) LMNAMAOAALDH1A1HSD17B10KMT2A
SCHEMBL278741 0.75 KMT2A (0.50) LMNAMAOAALDH1A1HSD17B10KMT2A
SCHEMBL19004692 0.75 HSPA1A (0.38) TSHRLMNATNKS2PBRM1MAOA
SCHEMBL454276 0.75 HSPA1A (0.38) TSHRLMNATNKS2PBRM1MAOA
SCHEMBL15704498 0.75 HSPA1A (0.38) TSHRLMNATNKS2PBRM1MAOA
SCHEMBL20884997 0.73 APP (0.33) ALDH1A1KDM4E
SCHEMBL21740555 0.73 CHRNB2 (0.36) TNKS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024059825-A1 SYSTEMS AND METHODS FOR QUANTIFYING USER OBSERVED VISUALIZATION OF FLUORESCENCE IMAGING AGENTS STRYKER CORPORATION (US) 2024-03-21 WO disclosed
US-10301203-B2 Chloroperoxidase-catalyzed degradation of pharmaceutical pollutants in wastewater THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) 2019-05-28 US disclosed
US-9938176-B1 Chloroperoxidase-catalyzed degradation of pharmaceutical pollutants in wastewater THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) 2018-04-10 US disclosed
EP-2471785-B1 Novel thiophene-based dye and preparation thereof DONGJIN SEMICHEM CO LTD (KR) 2017-04-19 EP disclosed
US-9377466-B2 Compounds and methods MODPRO AB (SE) 2016-06-28 US disclosed
US-9377466-B2 Compounds and methods MODPRO AB (SE) 2016-06-28 US disclosed
US-20160083426-A1 NON-BENZENOID AROMATIC SYSTEMS FOR IMAGING, MONITORING AND THERAPY MEDIBEACON INC. (US) 2016-03-24 US disclosed
US-9226980-B2 Azulene and azaazulene systems for imaging, monitoring and therapy MEDIBEACON INC. (US) 2016-01-05 US disclosed
EP-2471784-B1 Novel thiophene-based dye and preparation thereof DONGJIN SEMICHEM CO LTD (KR) 2015-07-08 EP disclosed
US-20130261013-A1 Compounds and Methods MODPRO AB (SE) 2013-10-03 US disclosed
EP-2471784-A1 Novel thiophene-based dye and preparation thereof Dongjin Semichem Co., Ltd. (KR) 2012-07-04 EP disclosed
WO-2012032068-A2 COMPOUNDS AND METHODS MODPRO AB (SE) 2012-03-15 WO disclosed
WO-2011031915-A2 NON-BENZENOID AROMATIC SYSTEMS FOR IMAGING, MONITORING AND THERAPY MALLINCKRODT INC. (US) 2011-03-17 WO disclosed
US-20100061928-A1 LABELLED ANALOGUES OF HALOBENZAMIDES AS RADIOPHARMACEUTICALS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2010-03-11 US disclosed
US-7598019-B2 Method for cleavage of labile functional groups from chemical compounds UNIVERSITAT KONSTANZ (DE) 2009-10-06 US disclosed
US-7598019-B2 Method for cleavage of labile functional groups from chemical compounds UNIVERSITAT KONSTANZ (DE) 2009-10-06 US disclosed
US-7442447-B2 Binaphthol based chromophores for the fabrication of blue organic light emitting diodes THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-10-28 US disclosed
US-7442447-B2 Binaphthol based chromophores for the fabrication of blue organic light emitting diodes THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-10-28 US disclosed
US-7205311-B2 Therapeutic acridone and acridine compounds CANCER RESEARCH TECHNOLOGY LIMITED 2007-04-17 US disclosed
US-7205311-B2 Therapeutic acridone and acridine compounds CANCER RESEARCH TECHNOLOGY LIMITED 2007-04-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100061928-A1 LABELLED ANALOGUES OF HALOBENZAMIDES AS RADIOPHARMACEUTICALS HRH3, H1-3, HRH4 TSHR 28/4885LMNA 2206/4885TNKS2 3640/4885
US-20160083426-A1 NON-BENZENOID AROMATIC SYSTEMS FOR IMAGING, MONITORING AND THERAPY PAH, AHR, ALK TSHR 2281/4885LMNA 3680/4885TNKS2 1361/4885
US-20130261013-A1 Compounds and Methods NOS2, NOS1, NOS3 TSHR 972/4885LMNA 2872/4885TNKS2 3510/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.