Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 10/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 5/20 | 1.00 |
| ▸ | SERPINA6 | P08185 | 4/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | SHBG | P04278 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | KCNA1 | Q09470 | 1/20 | 1.00 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 1.00 |
| ▸ | FNTA | P49354 | 5/20 | 0.78 |
| ▸ | FNTB | P49356 | 5/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.78 |
| ▸ | BLM | P54132 | 2/20 | 0.78 |
| ▸ | MEN1 | O00255 | 2/20 | 0.78 |
| ▸ | AR | P10275 | 1/20 | 0.78 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cortisone SCHEMBL4888 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1SERPINA6TSHRLMNA | |
| Cortisone SCHEMBL6535496 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1SERPINA6TSHRLMNA | |
| Cortisone SCHEMBL13026135 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1SERPINA6TSHRLMNA | |
| Cortisone SCHEMBL13332835 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1SERPINA6TSHRLMNA | |
| Cortisone SCHEMBL9926754 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1SERPINA6TSHRLMNA | |
| Cortisone SCHEMBL28542114 | 0.99 | HSD17B10 (0.98) | HSD17B10NR3C1SERPINA6TSHRLMNA | |
| Cortisone SCHEMBL5082086 | 0.99 | HSD17B10 (0.98) | HSD17B10NR3C1SERPINA6TSHRLMNA | |
| Cortisone SCHEMBL28537808 | 0.99 | HSD17B10 (0.98) | HSD17B10NR3C1SERPINA6TSHRLMNA | |
| Cortisone SCHEMBL5082082 | 0.99 | HSD17B10 (0.98) | HSD17B10NR3C1SERPINA6TSHRLMNA | |
| Cortisone SCHEMBL27538706 | 0.99 | HSD17B10 (0.98) | HSD17B10NR3C1SERPINA6TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200199170-A1 | COMPOUNDS HAVING ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITY | UNIV DEGLI STUDI DI FERRARA (IT) | 2020-06-25 | — | — | US | disclosed |
| WO-2017037081-A1 | COMPOUNDS HAVING ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITY | Università degli Studi di Ferrara (IT) | 2017-03-09 | — | — | WO | disclosed |
| US-20120041207-A1 | Compound | STERIX LIMITED (GB) | 2012-02-16 | — | — | US | disclosed |
| US-20110112151-A1 | COMPOUND CAPABLE OF INHIBITING 11-BETA HYDROXYSTERIOD DEHYDROGENASE | STERIX LIMITED (GB) | 2011-05-12 | — | — | US | disclosed |
| US-20110009448-A1 | Compound | STERIX LIMITED | 2011-01-13 | — | — | US | disclosed |
| US-7786152-B2 | Compound | STERIX LIMITED (GB) | 2010-08-31 | — | — | US | disclosed |
| US-20090042929-A1 | 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors | STERIX LIMITED (GB) | 2009-02-12 | — | — | US | disclosed |
| US-20080114042-A1 | Inhibiting 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD); use of sulfonamide-substituted N-heterocyclics including pyrroles, oxazoles, thiazoles, imidazoles and their fused analogs to treat diabetes, obesity, hypertension, arthritis, asthma, osteoporosis, breast cancer | STERIX LIMITED (GB) | 2008-05-15 | — | — | US | disclosed |
| US-7309715-B2 | Compound | STERIX LIMITED (GB) | 2007-12-18 | — | — | US | disclosed |
| US-20070249571-A1 | Novel conjugate compounds and dermatological compositions thereof | TAMARKIN PHARMACEUTICALS (IL) | 2007-10-25 | — | — | US | disclosed |
| US-20070249571-A1 | Novel conjugate compounds and dermatological compositions thereof | TAMARKIN PHARMACEUTICALS (IL) | 2007-10-25 | — | — | US | disclosed |
| US-20070244108-A1 | Phenylsulfonamide Derivatives for Use as 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors | STERIX LIMITED (GB) | 2007-10-18 | — | — | US | disclosed |
| US-7230020-B2 | 11β-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2007-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200199170-A1 | COMPOUNDS HAVING ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITY | LPO, C5, MPO | HSD17B10 328/4885NR3C1 759/4885SERPINA6 1598/4885 |
| US-20080114042-A1 | Inhibiting 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD); use of sulfonamide-substituted N-heterocyclics including pyrroles, oxazoles, thiazoles, imidazoles and their fused analogs to treat diabetes, obesity, hypertension, arthritis, asthma, osteoporosis, breast cancer | HSD11B1, HSD3B1, HSD11B2 | HSD17B10 33/4885NR3C1 32/4885SERPINA6 1202/4885 |
| US-20070244108-A1 | Phenylsulfonamide Derivatives for Use as 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors | HSD3B1, HSD3B2, HSD11B1 | HSD17B10 19/4885NR3C1 241/4885SERPINA6 3494/4885 |
| US-20070249571-A1 | Novel conjugate compounds and dermatological compositions thereof | CYP24A1, VDR, CYP2R1 | HSD17B10 37/4885NR3C1 114/4885SERPINA6 132/4885 |
| US-20090042929-A1 | 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors | HSD3B1, HSD3B2, HSD11B1 | HSD17B10 13/4885NR3C1 82/4885SERPINA6 2508/4885 |
| US-20110112151-A1 | COMPOUND CAPABLE OF INHIBITING 11-BETA HYDROXYSTERIOD DEHYDROGENASE | HSD11B1, HSD11B2, HSD3B1 | HSD17B10 20/4885NR3C1 639/4885SERPINA6 3728/4885 |
| US-20110009448-A1 | Compound | NR4A1, GPR6, PRMT6 | HSD17B10 1003/4885NR3C1 47/4885SERPINA6 2930/4885 |
| US-20120041207-A1 | Compound | NR4A1, GPR6, PRMT6 | HSD17B10 1003/4885NR3C1 47/4885SERPINA6 2930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.