Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.41 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9381426 | 0.77 | CALM1 (0.41) | TSHRCALM1NR1H2NR1H3ALDH1A1 | |
| SCHEMBL2437697 | 0.75 | HTR6 (0.43) | ALDH1A1HTR6MEN1KMT2A | |
| SCHEMBL19468081 | 0.70 | NR1H2 (0.35) | TSHRCALM1NR1H2NR1H3ALDH1A1 | |
| SCHEMBL4406015 | 0.69 | CNR2 (0.50) | TSHRCALM1ALDH1A1CNR1CNR2 | |
| SCHEMBL28347455 | 0.68 | HDAC6 (0.39) | ALDH1A1L3MBTL1 | |
| SCHEMBL794238 | 0.68 | TSHR (0.41) | TSHRCALM1TDP2KDM4CNR1H2 | |
| SCHEMBL460058 | 0.68 | CALM1 (0.55) | TSHRCALM1ALDH1A1MEN1KMT2A | |
| SCHEMBL31201754 | 0.67 | TDP2 (0.51) | TSHRCALM1TDP2KDM4CNR1H2 | |
| SCHEMBL15885877 | 0.67 | EPHX2 (0.58) | TSHRCALM1KDM4CALDH1A1LTB4R | |
| SCHEMBL2614741 | 0.67 | CALM1 (0.61) | TSHRCALM1ALDH1A1HTR6HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9580386-B2 | Substituted 4-aminocyclohexane derivatives | GRÜNENTHAL (DE) | 2017-02-28 | — | — | US | disclosed |
| EP-2260022-B1 | SUBSTITUTED CYCLOHEXYLDIAMINES | GRUENENTHAL GMBH (DE) | 2017-01-04 | — | — | EP | disclosed |
| US-9403767-B2 | Substituted 4-aminocyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2016-08-02 | — | — | US | disclosed |
| EP-2280941-B1 | (HETERO-)ARYL CYCLOHEXANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2015-05-06 | — | — | EP | disclosed |
| US-20140357634-A1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2014-12-04 | — | — | US | disclosed |
| US-8835689-B2 | Substituted 4-aminocyclohexane derivatives | Grünenthal GmbH (DE) | 2014-09-16 | — | — | US | disclosed |
| EP-2271613-B1 | HYDROXYMETHYLCYCLOHEXYLAMINES | GRUENENTHAL GMBH (DE) | 2014-06-18 | — | — | EP | disclosed |
| US-20130197095-A1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2013-08-01 | — | — | US | disclosed |
| US-8357705-B2 | Substituted cyclohexyldiamines | GRUENENTHAL GMBH (DE) | 2013-01-22 | — | — | US | disclosed |
| EP-2518052-A1 | Substituted 4-aminocyclohexane derivatives | Grünenthal GmbH (DE) | 2012-10-31 | — | — | EP | disclosed |
| EP-2257526-B1 | SPIRO(5.5)UNDECANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2011-12-14 | — | — | EP | disclosed |
| EP-2260042-B1 | SUBSTITUTED SPIROCYCLIC CYCLOHEXANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2011-09-21 | — | — | EP | disclosed |
| US-7977370-B2 | (Hetero)aryl cyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2011-07-12 | — | — | US | disclosed |
| US-20110059999-A1 | Hydroxymethylcyclohexylamines | Grünenthal GmbH (DE) | 2011-03-10 | — | — | US | disclosed |
| EP-2268652-A2 | PLATINUM-N-HETEROCYCLIC CARBENE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2011-01-05 | — | — | EP | disclosed |
| US-20090247573-A1 | (HETERO)ARYL CYCLOHEXANE DERIVATIVES | GRUNENTHAL GMBH (DE) | 2009-10-01 | — | — | US | disclosed |
| US-20090247505-A1 | SPIRO(5.5)UNDECANE DERIVATIVES | GRUNENTHAL GMBH (DE) | 2009-10-01 | — | — | US | disclosed |
| US-20090247561-A1 | SUBSTITUTED SPIROCYCLIC CYCLOHEXANE DERIVATIVES | GRUNENTHAL GMBH (DE) | 2009-10-01 | — | — | US | disclosed |
| US-20090247591-A1 | SUBSTITUTED CYCLOHEXYLDIAMINES | GRUNENTHAL GMBH (DE) | 2009-10-01 | — | — | US | disclosed |
| US-20090247530-A1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES | GRUNENTHAL GMBH (DE) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140357634-A1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES | OPRL1, OPRK1, OPRD1 | TSHR 1323/4885CALM1 1022/4885TDP2 3763/4885 |
| US-20090247530-A1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES | OPRL1, OPRK1, OPRD1 | TSHR 1323/4885CALM1 1022/4885TDP2 3763/4885 |
| US-20090247573-A1 | (HETERO)ARYL CYCLOHEXANE DERIVATIVES | OPRL1, OPRM1, OPRD1 | TSHR 968/4885CALM1 684/4885TDP2 4200/4885 |
| US-20110059999-A1 | Hydroxymethylcyclohexylamines | OPRL1, OPRM1, OPRD1 | TSHR 2668/4885CALM1 1097/4885TDP2 2998/4885 |
| US-20090247505-A1 | SPIRO(5.5)UNDECANE DERIVATIVES | OPRL1, OPRD1, OPRM1 | TSHR 1251/4885CALM1 1832/4885TDP2 4680/4885 |
| US-20090247591-A1 | SUBSTITUTED CYCLOHEXYLDIAMINES | OPRL1, OPRD1, OPRK1 | TSHR 1327/4885CALM1 555/4885TDP2 4145/4885 |
| US-20090247561-A1 | SUBSTITUTED SPIROCYCLIC CYCLOHEXANE DERIVATIVES | OPRL1, OPRK1, OPRD1 | TSHR 1180/4885CALM1 814/4885TDP2 4689/4885 |
| US-20130197095-A1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES | OPRL1, OPRK1, OPRD1 | TSHR 1323/4885CALM1 1022/4885TDP2 3763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.