Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13752339 | 0.93 | L3MBTL1 (0.43) | L3MBTL1HTTLMNASMN1; SMN2SLC6A4 | |
| SCHEMBL14636285 | 0.90 | NPSR1 (0.44) | L3MBTL1HTTLMNASMN1; SMN2SLC6A4 | |
| SCHEMBL872624 | 0.86 | SLC6A4 (0.53) | L3MBTL1SLC6A4HTR2AMAPTCHRM1 | |
| SCHEMBL967886 | 0.85 | L3MBTL1 (0.51) | L3MBTL1HTTLMNASMN1; SMN2SLC6A4 | |
| SCHEMBL13752342 | 0.80 | L3MBTL1 (0.43) | L3MBTL1HTTLMNASMN1; SMN2SLC6A4 | |
| SCHEMBL8153873 | 0.78 | L3MBTL1 (0.49) | L3MBTL1HTTLMNASMN1; SMN2SLC6A4 | |
| SCHEMBL7400584 | 0.77 | CHRM1 (0.65) | L3MBTL1LMNASLC6A4HTR2AKCNH2 | |
| SCHEMBL10094756 | 0.76 | SLC6A4 (0.37) | SMN1; SMN2SLC6A4HTR2AKCNH2MAPT | |
| SCHEMBL9995320 | 0.76 | SLC6A4 (0.52) | SLC6A4HTR2AKCNH2MAPTCHRM1 | |
| SCHEMBL10093147 | 0.73 | SLC6A4 (0.51) | L3MBTL1HTTSLC6A4HTR2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159549-A1 | METHOD FOR PREPARATION OF ASENAPINE | ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) | 2023-05-25 | — | — | US | disclosed |
| US-20230159549-A1 | METHOD FOR PREPARATION OF ASENAPINE | ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) | 2023-05-25 | — | — | US | disclosed |
| US-11535628-B2 | Method for preparation of Asenapine | ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) | 2022-12-27 | — | — | US | disclosed |
| EP-4015519-A1 | METHOD OF PREPARING ASENAPINE | Zhejiang Ausun Pharmaceutical Co., Ltd. (CN) | 2022-06-22 | — | — | EP | disclosed |
| WO-2021027813-A1 | METHOD OF PREPARING ASENAPINE | 浙江奥翔药业股份有限公司 | 2021-02-18 | — | — | WO | disclosed |
| US-20210047339-A1 | METHOD FOR PREPARATION OF ASENAPINE | ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) | 2021-02-18 | — | — | US | disclosed |
| EP-2468751-B1 | Processes for the preparation of 5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole | MEDICHEM SA (ES) | 2016-03-16 | — | — | EP | disclosed |
| CN-103760280-A | Method for separating and measuring asenapine intermediate related substances by liquid chromatography | AVENTIS PHARMA HAINAN CO LTD | 2014-04-30 | — | — | CN | disclosed |
| US-8580972-B2 | Processes for the preparation of 5-chloro-2-methyl-2,3,3A,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole | MEDICHEM, S.A. (ES) | 2013-11-12 | — | — | US | disclosed |
| US-8580972-B2 | Processes for the preparation of 5-chloro-2-methyl-2,3,3A,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole | MEDICHEM, S.A. (ES) | 2013-11-12 | — | — | US | disclosed |
| WO-2013024492-A2 | A PROCESS FOR THE PREPARATION OF ASENAPINE AND NOVEL SALTS THEREOF | MEGAFINE PHARMA (P) LTD. (IN) | 2013-02-21 | — | — | WO | disclosed |
| US-20120165545-A1 | PROCESSES FOR THE PREPARATION OF 5-CHLORO-2-METHYL-2,3,3A,12b-TETRAHYDRO-1H-DIBENZO[2,3:6,7]OXEPINO[4,5-c]PYRROLE | MEDICHEM, S.A. (ES) | 2012-06-28 | — | — | US | disclosed |
| US-20120165545-A1 | PROCESSES FOR THE PREPARATION OF 5-CHLORO-2-METHYL-2,3,3A,12b-TETRAHYDRO-1H-DIBENZO[2,3:6,7]OXEPINO[4,5-c]PYRROLE | MEDICHEM, S.A. (ES) | 2012-06-28 | — | — | US | disclosed |
| EP-2468751-A2 | Processes for the preparation of 5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole | Medichem, S.A. (ES) | 2012-06-27 | — | — | EP | disclosed |
| US-20090209608-A1 | DEUTERIUM-ENRICHED ASENAPINE | PROTIA, LLC (US) | 2009-08-20 | — | — | US | disclosed |
| US-20090209608-A1 | DEUTERIUM-ENRICHED ASENAPINE | PROTIA, LLC (US) | 2009-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159549-A1 | METHOD FOR PREPARATION OF ASENAPINE | CYP3A5, QDPR, SPR | L3MBTL1 4733/4885HTT 1107/4885LMNA 1191/4885 |
| US-11535628-B2 | Method for preparation of Asenapine | CYP3A5, QDPR, SPR | L3MBTL1 4733/4885HTT 1107/4885LMNA 1191/4885 |
| US-20090209608-A1 | DEUTERIUM-ENRICHED ASENAPINE | NSD2, DRD2, SNRPD2 | L3MBTL1 4218/4885HTT 442/4885LMNA 1972/4885 |
| US-20210047339-A1 | METHOD FOR PREPARATION OF ASENAPINE | CYP3A5, QDPR, SPR | L3MBTL1 4733/4885HTT 1107/4885LMNA 1191/4885 |
| US-20120165545-A1 | PROCESSES FOR THE PREPARATION OF 5-CHLORO-2-METHYL-2,3,3A,12b-TETRAHYDRO-1H-DIBENZO[2,3:6,7]OXEPINO[4,5-c]PYRROLE | DHPS, CYP3A5, ALKBH5 | L3MBTL1 4473/4885HTT 2578/4885LMNA 4222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.