Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 3/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PRCP | P42785 | 2/20 | 0.32 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1487594 | 0.82 | BRD4 (0.41) | OPRK1BRD4CREBBPADRA1AADRA1B | |
| SCHEMBL1010063 | 0.75 | KDM6B (0.36) | OPRK1ALDH1A1PRCPOPRM1SLC22A1 | |
| SCHEMBL4019842 | 0.69 | ADRA2A (0.46) | OPRK1ALDH1A1KDM4ESMN1; SMN2OPRM1 | |
| SCHEMBL1011331 | 0.69 | DRD2 (0.40) | PRCPGID4S1PR1S1PR3SLC22A1 | |
| SCHEMBL8027646 | 0.68 | BRD4 (0.38) | OPRK1BRD4CREBBPALDH1A1KDM4E | |
| SCHEMBL1011390 | 0.66 | BRD4 (0.41) | OPRK1BRD4CREBBPADRA1AADRA1B | |
| SCHEMBL4020702 | 0.64 | PRCP (0.65) | OPRK1ALDH1A1KDM4ESMN1; SMN2PRCP | |
| SCHEMBL4020963 | 0.64 | PRCP (0.65) | OPRK1ALDH1A1KDM4ESMN1; SMN2PRCP | |
| SCHEMBL33531851 | 0.62 | GID4 (0.56) | ALDH1A1KDM4EPRCPGID4SLC22A1 | |
| SCHEMBL1011582 | 0.61 | HTR1A (0.44) | BRD4GID4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054416-B1 | SUBSTITUTED PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO KGAA (DE) | 2011-01-05 | — | — | EP | disclosed |