Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | GID4 | Q8IVV7 | 2/20 | 0.37 |
| ▸ | PRCP | P42785 | 2/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1487596 | 0.76 | PDE9A (0.38) | DRD2GID4HTR2CHTR2BKDM1A | |
| SCHEMBL4019842 | 0.71 | ADRA2A (0.46) | — | |
| SCHEMBL4020963 | 0.70 | PRCP (0.65) | PRCPSLC22A1 | |
| SCHEMBL4020702 | 0.70 | PRCP (0.65) | PRCPSLC22A1 | |
| SCHEMBL1009372 | 0.69 | OPRK1 (0.36) | GID4PRCPSLC22A1S1PR1S1PR3 | |
| SCHEMBL33532651 | 0.66 | GID4 (0.52) | DRD2GID4PRCPSLC22A1HTR2C | |
| SCHEMBL33531851 | 0.66 | GID4 (0.56) | GID4PRCPSLC22A1HTR2CHTR2B | |
| SCHEMBL25193256 | 0.64 | DRD2 (0.45) | DRD2HTR2CHTR2BS1PR1SLC6A4 | |
| SCHEMBL12420776 | 0.64 | DRD2 (0.45) | DRD2S1PR1S1PR3DRD1DRD4 | |
| SCHEMBL2196969 | 0.64 | KMT2A (0.50) | DRD2S1PR1DRD1DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054416-B1 | SUBSTITUTED PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO KGAA (DE) | 2011-01-05 | — | — | EP | disclosed |