Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB2 | O60825 | 6/20 | 0.48 |
| ▸ | PFKFB1 | P16118 | 6/20 | 0.48 |
| ▸ | PFKFB3 | Q16875 | 6/20 | 0.48 |
| ▸ | AS3MT | Q9HBK9 | 5/20 | 0.48 |
| ▸ | NSD2 | O96028 | 3/20 | 0.48 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13152055 | 0.94 | MTNR1A (0.46) | PFKFB2PFKFB1PFKFB3AS3MTNSD2 | |
| SCHEMBL13153378 | 0.93 | NPC1 (0.42) | PFKFB2PFKFB1PFKFB3AS3MTNSD2 | |
| SCHEMBL10097607 | 0.92 | MTNR1A (0.46) | PFKFB2PFKFB1PFKFB3AS3MTNSD2 | |
| SCHEMBL13152174 | 0.89 | L3MBTL1 (0.42) | PFKFB2PFKFB1PFKFB3AS3MTNSD2 | |
| SCHEMBL10097782 | 0.89 | L3MBTL1 (0.42) | PFKFB2PFKFB1PFKFB3AS3MTNSD2 | |
| SCHEMBL13152172 | 0.89 | MAPT (0.44) | PFKFB2PFKFB1PFKFB3AS3MTNSD2 | |
| SCHEMBL10095377 | 0.88 | PFKFB2 (0.55) | PFKFB2PFKFB1PFKFB3AS3MTNSD2 | |
| SCHEMBL10249955 | 0.87 | MTNR1A (0.46) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL10256083 | 0.86 | KMT2A (0.50) | PFKFB2PFKFB1PFKFB3AS3MTNSD2 | |
| SCHEMBL10097294 | 0.85 | MAPT (0.41) | NPC1RAB9AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120027721-A1 | HCV Inhibitor and Therapeutic Agent Combinations | PTC THERAPEUTICS, INC. (US) | 2012-02-02 | — | — | US | disclosed |
| US-20120009142-A1 | METHODS FOR TREATING HEPATITIS C | PTC THERAPEUTICS, INC. (US) | 2012-01-12 | — | — | US | disclosed |
| WO-2010118009-A1 | HCV INHIBITOR AND THERAPEUTIC AGENT COMBINATIONS | PTC THERAPEUTICS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120009142-A1 | METHODS FOR TREATING HEPATITIS C | OAT, HAVCR2, HCCS | PFKFB2 4129/4885PFKFB1 4133/4885PFKFB3 4055/4885 |
| US-20120027721-A1 | HCV Inhibitor and Therapeutic Agent Combinations | HAVCR2, SERPINB1, ENPEP | PFKFB2 4202/4885PFKFB1 4102/4885PFKFB3 4231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.