Sugi Predict

Sugi Predict / Compounds / SCHEMBL1010378

SCHEMBL1010378

SCHEMBL1010378

C[C@@H]1NCCc2ccccc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ PRCP P42785 8/20 0.61
▸ GAA P10253 1/20 0.56
▸ HTR2A P28223 1/20 0.56
▸ HTR2C P28335 1/20 0.56
▸ HTR2B P41595 1/20 0.56
▸ DRD2 P14416 2/20 0.52
▸ TSHR P16473 2/20 0.52
▸ MAOA P21397 2/20 0.52
▸ KDM4E B2RXH2 1/20 0.52
▸ CYP2C9 P11712 1/20 0.52
▸ DRD3 P35462 1/20 0.52
▸ HIF1A Q16665 1/20 0.52
▸ HSD17B10 Q99714 1/20 0.52
▸ DRD4 P21917 1/20 0.52
▸ SLC22A1 O15245 1/20 0.51
▸ RECQL P46063 1/20 0.51
▸ NPSR1 Q6W5P4 1/20 0.51
▸ GID4 Q8IVV7 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29658057 1.00 PRCP (0.61) PRCPGAAHTR2AHTR2CHTR2B
SCHEMBL29658056 1.00 PRCP (0.61) PRCPGAAHTR2AHTR2CHTR2B
SCHEMBL1011611 1.00 PRCP (0.61) PRCPGAAHTR2AHTR2CHTR2B
SCHEMBL29658050 1.00 PRCP (0.61) PRCPGAAHTR2AHTR2CHTR2B
SCHEMBL327738 1.00 PRCP (0.61) PRCPGAAHTR2AHTR2CHTR2B
SCHEMBL31069871 1.00 PRCP (0.61) PRCPGAAHTR2AHTR2CHTR2B
SCHEMBL29384464 1.00 PRCP (0.61) PRCPGAAHTR2AHTR2CHTR2B
Hydrochloric Acid SCHEMBL2262788 0.98 PRCP (0.59) PRCPGAAHTR2AHTR2CHTR2B
Bromide SCHEMBL17674654 0.98 PRCP (0.59) PRCPGAAHTR2AHTR2CHTR2B
Hydrochloric Acid SCHEMBL19349458 0.98 PRCP (0.59) PRCPGAAHTR2AHTR2CHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105669642-B Preparation method of loflupridine hydrochloride 江苏天士力帝益药业有限公司 2020-06-09 — — CN claimed
US-9981917-B2 Preparation method for revaprazan hydrochloride JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. (CN) 2018-05-29 — — US claimed
US-20170267646-A1 PREPARATION METHOD FOR REVAPRAZAN HYDROCHLORIDE JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. (CN) 2017-09-21 — — US claimed
US-20150218103-A1 GAPDH CASCADE INHIBITOR COMPOUNDS AND METHODS OF USE AND TREATMENT OF STRESS INDUCED DISORDERS INCLUDING MENTAL ILLNESS UNIV JOHNS HOPKINS (US) 2015-08-06 — — US claimed
WO-2014035707-A1 GAPDH CASCADE INHIBITOR COMPOUNDS AND METHODS OF USE AND TREATMENT OF STRESS INDUCED DISORDERS INCLUDING MENTAL ILLNESS THE JOHNS HOPKINS UNIVERSITY (US) 2014-03-06 — — WO claimed
EP-0900214-B1 PROCESS FOR PREPARATION OF PYRIMIDINE DERIVATIVES YUHAN CORP (KR) 2001-09-26 — — EP claimed
US-5990311-A Process for preparation of pyrimidine derivatives UHAN CORPORATION (KR) 1999-11-23 — — US claimed
EP-0900214-A1 PROCESS FOR PREPARATION OF PYRIMIDINE DERIVATIVES Yuhan Corporation (KR) 1999-03-10 — — EP claimed
WO-1998018784-A1 PROCESS FOR PREPARATION OF PYRIMIDINE DERIVATIVES YUHAN CORPORATION (KR) 1998-05-07 — — WO claimed
WO-1997042186-A1 PROCESS FOR PREPARATION OF PYRIMIDINE DERIVATIVES YUHAN CORPORATION (KR) 1997-11-13 — — WO claimed
US-20230202993-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE BEETLEJUICE SA LLC, AS PURCHASER AGENT 2023-06-29 — — US disclosed
US-20230202993-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE BEETLEJUICE SA LLC, AS PURCHASER AGENT 2023-06-29 — — US disclosed
US-20220235082-A1 CATALYSTS THE UNIVERSITY OF WARWICK (GB) 2022-07-28 — — US disclosed
WO-2022125849-A1 PROGRANULIN MODULATORS AND METHODS OF USING THE SAME ARKUDA THERAPEUTICS (US) 2022-06-16 — — WO disclosed
US-20220072006-A1 PRO-DRUGS OF RILUZOLE AND THEIR METHOD OF USE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS BEETLEJUICE SA LLC, AS PURCHASER AGENT 2022-03-10 — — US disclosed
EP-0900214-A1 PROCESS FOR PREPARATION OF PYRIMIDINE DERIVATIVES Yuhan Corporation (KR) 1999-03-10 — — EP disclosed
US-5750531-A ANTISECRETORY AGENTS FOR THE TREATMENT OF PEPTIC ULCER YUHAN CORPORATION (KR) 1998-05-12 — — US disclosed
WO-1998018784-A1 PROCESS FOR PREPARATION OF PYRIMIDINE DERIVATIVES YUHAN CORPORATION (KR) 1998-05-07 — — WO disclosed
WO-1997042186-A1 PROCESS FOR PREPARATION OF PYRIMIDINE DERIVATIVES YUHAN CORPORATION (KR) 1997-11-13 — — WO disclosed
US-5686458-A Quinazoline deriviates for treating peptic ulcer YUHAN CORPORATION (KR) 1997-11-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150218103-A1 GAPDH CASCADE INHIBITOR COMPOUNDS AND METHODS OF USE AND TREATMENT OF STRESS INDUCED DISORDERS INCLUDING MENTAL ILLNESS GAPDH, CREBBP, PDK1 PRCP 2662/4885GAA 73/4885HTR2A 2836/4885
US-20230202993-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE APEH, UGT1A9, ALDH3A1 PRCP 131/4885GAA 541/4885HTR2A 2167/4885
US-20170267646-A1 PREPARATION METHOD FOR REVAPRAZAN HYDROCHLORIDE DPYD, QDPR, REV1 PRCP 1513/4885GAA 561/4885HTR2A 712/4885
US-20220072006-A1 PRO-DRUGS OF RILUZOLE AND THEIR METHOD OF USE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS CYP1A2, CYP3A5, UGT1A1 PRCP 184/4885GAA 72/4885HTR2A 535/4885
US-20220235082-A1 CATALYSTS TST, TCP1, CCT3 PRCP 3327/4885GAA 941/4885HTR2A 4650/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.