Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.68 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.60 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.60 |
| ▸ | HMGCR | P04035 | 2/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL526489 | 1.00 | RXRA (0.68) | RXRAPRKAA2NR1I2NR4A2PDE4D | |
| SCHEMBL526488 | 1.00 | RXRA (0.68) | RXRAPRKAA2NR1I2NR4A2PDE4D | |
| Nitrous Acid SCHEMBL6665052 | 0.93 | RXRA (0.67) | RXRAPRKAA2NR1I2NR4A2PDE4D | |
| Nitrous Acid SCHEMBL7524974 | 0.93 | RXRA (0.67) | RXRAPRKAA2NR1I2NR4A2PDE4D | |
| SCHEMBL15247428 | 0.91 | RXRA (0.56) | RXRAPRKAA2NR1I2NR4A2PDE4D | |
| SCHEMBL18947956 | 0.87 | RXRA (0.64) | RXRAPRKAA2NR1I2NR4A2PDE4D | |
| SCHEMBL12192330 | 0.87 | NR1I2 (0.65) | RXRAPRKAA2NR1I2NR4A2PDE4D | |
| SCHEMBL18696397 | 0.86 | RXRA (0.65) | RXRAPRKAA2NR1I2NR4A2PDE4D | |
| SCHEMBL29466456 | 0.86 | RXRA (0.75) | RXRAPRKAA2NR1I2NR4A2PDE4D | |
| SCHEMBL1844436 | 0.86 | RXRA (0.75) | RXRAPRKAA2NR1I2NR4A2PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230025343-A1 | CARBONYL REDUCTASE, NUCLEIC ACID ENCODING SAME, AND METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND USING SAME | API CORPORATION (JP) | 2023-01-26 | — | — | US | disclosed |
| EP-2788342-B1 | PROCESS FOR THE PREPARATION OF A STATIN PRECURSOR | DSM SINOCHEM PHARM NL BV (NL) | 2018-01-24 | — | — | EP | disclosed |
| WO-2017137469-A1 | NOVEL CLASS OF COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASE | STICHTING KATHOLIEKE UNIVERSITEIT (NL) | 2017-08-17 | — | — | WO | disclosed |
| US-20170226061-A1 | CRYSTAL FORM OF QUINOLINE COMPOUND AND PROCESS FOR ITS PRODUCTION | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2017-08-10 | — | — | US | disclosed |
| US-9676743-B2 | Substituted 3-hydroxy-δ-lactones from epoxides | CORNELL UNIVERSITY (US) | 2017-06-13 | — | — | US | disclosed |
| US-9260423-B2 | Process for the preparation of a thioprecursor for statins | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2016-02-16 | — | — | US | disclosed |
| US-9260423-B2 | Process for the preparation of a thioprecursor for statins | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2016-02-16 | — | — | US | disclosed |
| US-9085538-B2 | Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof | LEK PHARMACEUTICALS D.D. (SI) | 2015-07-21 | — | — | US | disclosed |
| US-8987478-B2 | Process for the preparation of a statin precursor | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2015-03-24 | — | — | US | disclosed |
| US-8987478-B2 | Process for the preparation of a statin precursor | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2015-03-24 | — | — | US | disclosed |
| US-20140357864-A1 | PROCESS FOR THE PREPARATION OF A STATIN PRECURSOR | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2014-12-04 | — | — | US | disclosed |
| US-20140343292-A1 | PROCESS FOR THE PREPARATION OF A THIOPRECURSOR FOR STATINS | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2014-11-20 | — | — | US | disclosed |
| US-20140343292-A1 | PROCESS FOR THE PREPARATION OF A THIOPRECURSOR FOR STATINS | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2014-11-20 | — | — | US | disclosed |
| US-20140107339-A1 | SUBSTITUTED 3-HYDROXY-DELTA-LACTONES FROM EPOXIDES | CORNELL UNIVERSITY (US) | 2014-04-17 | — | — | US | disclosed |
| US-20140051854-A1 | PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES FOR THE SYNTHESIS OF STATINS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | LEK PHARMACEUTICALS D.D. (SI) | 2014-02-20 | — | — | US | disclosed |
| US-8530677-B2 | Substituted 3-hydroxy-delta-lactones from epoxides | CORNELL UNIVERSITY (US) | 2013-09-10 | — | — | US | disclosed |
| WO-2013083718-A1 | PROCESS FOR THE PREPARATION OF A STATIN PRECURSOR | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2013-06-13 | — | — | WO | disclosed |
| WO-2013083719-A1 | PROCESS FOR THE PREPARATION OF A THIOPRECURSOR FOR STATINS | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2013-06-13 | — | — | WO | disclosed |
| WO-2012013325-A1 | PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES FOR THE SYNTHESIS OF STATINS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | LEK PHARMACEUTICALS D.D. (SI) | 2012-02-02 | — | — | WO | disclosed |
| US-20110244016-A1 | MEDICAL IMPLANT HAVING A COATING COMPOSED OF OR CONTAINING AT LEAST ONE ACTIVE SUBSTANCE | BIOTRONIK AG (CH) | 2011-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140051854-A1 | PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES FOR THE SYNTHESIS OF STATINS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | HMGCR, PCSK9, FAH | RXRA 1879/4885PRKAA2 317/4885NR1I2 4025/4885 |
| US-20140357864-A1 | PROCESS FOR THE PREPARATION OF A STATIN PRECURSOR | HMGCR, PCSK9, DHCR7 | RXRA 512/4885PRKAA2 842/4885NR1I2 1706/4885 |
| US-20140343292-A1 | PROCESS FOR THE PREPARATION OF A THIOPRECURSOR FOR STATINS | HMGCR, TPMT, GRHPR | RXRA 606/4885PRKAA2 1337/4885NR1I2 1733/4885 |
| US-20170226061-A1 | CRYSTAL FORM OF QUINOLINE COMPOUND AND PROCESS FOR ITS PRODUCTION | VAT1, CACNA1A, VMP1 | RXRA 3742/4885PRKAA2 2496/4885NR1I2 3919/4885 |
| US-20140107339-A1 | SUBSTITUTED 3-HYDROXY-DELTA-LACTONES FROM EPOXIDES | EBP, CYP8B1, HSD3B2 | RXRA 539/4885PRKAA2 2398/4885NR1I2 1224/4885 |
| US-20110244016-A1 | MEDICAL IMPLANT HAVING A COATING COMPOSED OF OR CONTAINING AT LEAST ONE ACTIVE SUBSTANCE | CD44, BDNF, S100P | RXRA 1798/4885PRKAA2 4690/4885NR1I2 2800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.